Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern
Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern
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DOI：
10.1016/s0167-4781(00)00196-2
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发表时间：
2000-10-02
期刊：
影响因子：
--
通讯作者：
Bingle, L
中科院分区：
文献类型：
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作者：
Bingle, CD;Bingle, L
在这里，我们报告了 plunc 人类同源物的克隆和表征，plunc 是一种在上呼吸道和鼻咽区域特异性表达的小鼠基因。人类 plunc cDNA 编码 256 个氨基酸的富含亮氨酸的蛋白质，与鼠蛋白质有 72% 的一致性。 RNA印迹分析表明plunc的表达仅限于气管、上呼吸道、鼻咽上皮和唾液腺。人类plunc基因包含9个外显子，定位于染色体20q11.2。人类plunc的独特表达模式表明，它可能是一种有用的模型基因，可用于研究将基因特异性表达至上呼吸道的调节机制。 (C) 2000 Elsevier Science B.V. 保留所有权利。
Here we report the cloning and characterization of the human homologue of plunc, a murine gene expressed specifically in the upper airways and nasopharyngeal regions. The human plunc cDNA codes for a leucine-rich protein of 256 amino acids which is 72% identical to the murine protein. RNA blot analysis suggests that expression of plunc is restricted to the trachea, upper airway, nasopharyngeal epithelium and salivary gland. The human plunc gene contains nine exons and is localised to chromosome 20q11.2. The unique expression pattern of the human plunc suggest that it may prove a useful model gene with which to study the regulatory mechanisms which direct expression of genes specifically to the upper airways. (C) 2000 Elsevier Science B.V. All rights reserved.