Viral shedding in Chinese young adults with mild 2009 H1N1 influenza
Viral shedding in Chinese young adults with mild 2009 H1N1 influenza
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2009 年轻型 H1N1 流感中国年轻人的病毒排泄情况
DOI：
10.3760/cma.j.issn.0366-6999.2011.10.026
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发表时间：
2011-05-20
影响因子：
6.1
通讯作者：
Liu Yun-xi
中科院分区：
文献类型：
--
作者：
Jia Ning;Gao Yan;Liu Yun-xi
背景2009年H1N1流感病毒脱落的持续时间和在个体之间的传播，特别是在患有轻度疾病的年轻人群中，现在还不清楚。方法收集2009年9月至2010年1月期间67例2009年H1N1流感轻症患者和37例季节性流感患者的临床资料和鼻咽拭子，年龄18 ~ 35岁。采用真实的时间RT-PCR检测鼻咽拭子标本的病毒脱落情况。结果67例H1N1病毒感染者中，82.1%（55/67）有发热症状，季节性流感患者中高热（≥ 39 ℃）者较多（P < 0.05）;对于H1N1患者，症状发作和检测不到RNA之间的中位间隔为6天（4-10天）。但31.3%的患者在发病7天后仍有病毒脱落。发热消失和病毒RNA水平检测不到之间的中位时间间隔为3天（2-8天），17.9%的患者在体温正常化后6天发现病毒脱落。在季节性流感患者中，94.6%的患者在7天内检出病毒RNA。季节性流感从症状出现到RNA检测不到的中位间隔时间为4天（3-8天）。结论从发病起隔离7 d或发热和呼吸道症状消失后24 h，不足以阻断我国轻症青壮年间的传播。中华医学杂志2011;124（10）：1576-1579
Background The duration of viral shedding and the transmission of 2009 H1N1 influenza among individuals, especially among the younger population with mild illness, are not well understood now. The aim of this study was to determine the viral shedding of the young adult patients with mild 2009 H1N1 influenza in China.Methods From September 2009 to January 2010, the clinical data and serial nasopharyngeal swabs of 67 patients with 2009 H1N1 influenza and 37 patients with seasonal influenza aged from 18 years to 35 years were collected. The nasopharyngeal swab samples were detected by real time RT-PCR to determine the viral shedding. All the patients did not receive the antiviral therapy but Chinese medicine for detoxicating.Results Among the patients with H1N1 virus infection, 82.1% (55/67) patients presented with fever symptom, while more patients with high fever (>= 39 degrees C) were found in seasonal influenza patients (P < 0.05). For the H1N1 patients, the median interval between the symptom onset and the undetectable RNA was six days (4-10 days). But viral shedding was still found in 31.3% patients after 7 days following illness onset. The median interval between disappearance of fever and an undetectable viral RNA level was three days (2-8 days), and 17.9% patients were found to be viral shedding 6 days later after normalization of body temperature. For the seasonal influenza patients, 94.6% patients were detected out viral RNA within 7 days. The median interval of seasonal influenza between the symptom onset and the undetectable RNA was four days (3-8 days). The median interval between disappearance of fever and an undetectable viral RNA level was three days (2-6 days).Conclusion It suggests that 7 days isolation period from the illness onset or 24 hours after the resolution of fever and respiratory symptoms are not long enough to cut off the transmission among Chinese young adults with mild illness. Chin Med J 2011;124(10):1576-1579