Synthesis of leucascandrolide A via a spontaneous macrolactolization.
Synthesis of leucascandrolide A via a spontaneous macrolactolization.
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通过自发大环乳醇化合成 leucascandrolide A。
DOI：
10.1021/ja028428g
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发表时间：
2002
影响因子：
15
通讯作者：
Kozmin,SergeyA
中科院分区：
文献类型：
--
作者：
Wang,Ying;Janjic,Jelena;Kozmin,SergeyA
We have developed a concise, convergent, and stereocontrolled synthesis of (±)-leucascandrolide A (18 steps from commercially available precursors), featuring a complete relay of the initial stereochemical information via a series of diastereoselective transformations. Spontaneous macrolactolization discovered during this synthetic exercise has provided unprecedented access to this macrolide and demonstrated the possibility of accessing even large-ring systems in a highly controlled and efficient manner.
