Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects.
Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects.
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DOI：
10.1186/s13104-016-1980-z
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发表时间：
2016-03-22
影响因子：
1.8
通讯作者：
Toyo-oka K
中科院分区：
文献类型：
--
作者：
Cornell B;Toyo-oka K
7种14-3-3蛋白同工型与许多蛋白结合，并参与多种细胞事件，包括细胞周期、细胞分裂、细胞凋亡和癌症。我们已经发现14-3-3蛋白在发育中的皮层锥体神经元迁移中的重要性。在此，我们采用小鼠遗传学方法测试14-3-3蛋白在体内神经嵴细胞发育中的功能。我们发现14-3-3蛋白对神经嵴细胞的发育很重要，特别是对小鼠腹侧毛的色素沉着。我们从14-3-3ε/14-3-3ζ/Wnt1-Cre小鼠中获得的数据强烈表明14-3-3蛋白在黑素细胞谱系发育中的重要性。
The seven 14-3-3 protein isoforms bind to numerous proteins and are involved in a wide variety of cellular events, including the cell cycle, cell division, apoptosis and cancer. We previously found the importance of 14-3-3 proteins in neuronal migration of pyramidal neurons in the developing cortex. Here, we test the function of 14-3-3 proteins in the development of neural crest cells in vivo using mouse genetic approaches. We found that 14-3-3 proteins are important for the development of neural crest cells, in particular for the pigmentation of the fur on the ventral region of mice. Our data obtained from the 14-3-3ε/14-3-3ζ/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages.