Wegener's granulomatosis. Anatomic correlates, a proposed classification.
Wegener's granulomatosis. Anatomic correlates, a proposed classification.
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韦格纳肉芽肿病。
作者：
R. Deremee;Thomas J. McDonald;Harrison Eg;Coles Dt
根据 50 名韦格纳肉芽肿患者 10 年的经验，根据受累的解剖部位提出了新的分类：上呼吸道或耳、鼻和咽喉（指定为 E）、肺（L）和肾（K）。 ELK的所有组合都被看到了。该系统作为一个统一的概念提供，涵盖术语中线肉芽肿、全身或经典韦格纳肉芽肿病和有限韦格纳肉芽肿病。尽管使用皮质类固醇和免疫抑制剂治疗，仍有 14 名患者死亡。 13 名肾脏受累的患者存活了长达 114 个月；所有人都在服用免疫抑制剂。
Based on a 10-year experience with 50 patients who had Wegener's granulomatosis, a new classification is proposed based on anatomic site of involvement: upper airway or ear, nose, and throat (designated E), lung (L), and kidney (K). All combinations of ELK were seen. The system is offered as a unifying concept to embrace the terms midline granuloma, generalized or classic Wegener's granulomatosis, and limited Wegener's granulomatosis. Fourteen patients have died despite the use of corticosteroids and immunosuppressant therapy. Thirteen patients with renal involvement have survived for periods as long as 114 months; all were taking immunosuppressive agents.