Perspective: Evolution and detection of genetic robustness
Perspective: Evolution and detection of genetic robustness
复制标题
DOI：
10.1554/02-750r
复制
发表时间：
2003-09-01
期刊：
影响因子：
3.3
通讯作者：
Whitlock, MC
中科院分区：
文献类型：
--
作者：
de Visser, JAGM;Hermisson, J;Whitlock, MC
稳健性是指表型在面对扰动时的不变性。表型的稳健性出现在生物组织的不同水平，包括基因表达、蛋白质折叠、代谢流量、生理动态平衡、发育，甚至生物体的适应性。稳健性的机制是多样的，从RNA和蛋白质水平上的热力学稳定性到生物水平上的行为。表型对可遗传的扰动(例如突变)或不可遗传的扰动(例如天气)都是健壮的。在这里，我们主要关注第一种稳健性--遗传稳健性--并综述了三种日益增长的研究途径：(1)在自然界和实验室中测量遗传稳健性；(2)理解遗传稳健性的进化；以及(3)探索遗传稳健性对未来进化的影响。
Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding, metabolic flux, physiological homeostasis, development, and even organismal fitness. The mechanisms underlying robustness are diverse, ranging from thermodynamic stability at the RNA and protein level to behavior at the organismal level. Phenotypes can be robust either against heritable perturbations (e.g., mutations) or nonheritable perturbations (e.g., the weather). Here we primarily focus on the first kind of robustness-genetic robustness-and survey three growing avenues of research: (1) measuring genetic robustness in nature and in the laboratory; (2) understanding the evolution of genetic robustness; and (3) exploring the implications of genetic robustness for future evolution.