Dock protein family in brain development and neurological disease.
Dock protein family in brain development and neurological disease.
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码头蛋白家族在大脑发育和神经系统疾病中的作用
DOI：
10.4161/cib.26839
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发表时间：
2013-11-01
影响因子：
--
通讯作者：
Shi L
中科院分区：
文献类型：
--
作者：
Shi L
细胞质分裂献身者家族（Dock）是Rac和/或Cdc42 GTPases的非典型Rho鸟嘌呤核苷酸交换因子（GEFs）的一个蛋白质家族，在大脑发育的各种过程中起着关键作用。迄今为止，在哺乳动物系统中已确定了11名Docks成员。新出现的证据表明，Dock家族成员与几种神经退行性疾病和神经精神疾病有关，包括阿尔茨海默病和自闭症谱系障碍。本文综述了Dock蛋白家族在神经系统正常和病变过程中的作用的最新进展。此外，还讨论了码头的相互作用蛋白和分子调控。
The family of dedicator of cytokinesis (Dock), a protein family that belongs to the atypical Rho guanine nucleotide exchange factors (GEFs) for Rac and/or Cdc42 GTPases, plays pivotal roles in various processes of brain development. To date, 11 members of Docks have been identified in the mammalian system. Emerging evidence has suggested that members of the Dock family are associated with several neurodegenerative and neuropsychiatric diseases, including Alzheimer disease and autism spectrum disorders. This review summarizes recent advances on the understanding of the roles of the Dock protein family in normal and diseased processes in the nervous system. Furthermore, interacting proteins and the molecular regulation of Docks are discussed.