Cytokine profiling for prediction of symptomatic radiation-induced lung injury
Cytokine profiling for prediction of symptomatic radiation-induced lung injury
复制标题
DOI：
10.1016/j.ijrobp.2005.05.032
复制
发表时间：
2005-12-01
影响因子：
7
通讯作者：
Anscher, MS
中科院分区：
文献类型：
--
作者：
Hart, JP;Broadwater, G;Anscher, MS
目的：为了分析血浆细胞因子谱开始前的放射治疗，以确定一个细胞因子表型，与发展有症状的放射性肺损伤（SRILI）的风险相关的方法和材料：症状放射性肺损伤进行了评估，在55例（22与SRILI和33没有SRILI），根据修改后的国家癌症研究所共同的毒性标准。这些血浆样品通过多重悬浮珠阵列系统进行分析（Bio-Rad Laboratories; Hercules，CA），其包括以下细胞因子：白细胞介素（IL）-1 β、IL-2、IL-4、IL-5、IL-6、IL-7、IL-8、IL-10、IL-12 p70、IL-13、IL-17、粒细胞/巨噬细胞集落刺激因子、干扰素-γ、单核细胞趋化蛋白1、巨噬细胞炎性蛋白10、肿瘤坏死因子α和粒细胞集落刺激因子。结果：观察到有和没有SRILI的患者之间IL-8的中值存在显著差异。与随后发生SRILL的患者相比，未发生SRILL的患者的IL-8水平升高约4倍，在本研究中未发现任何其他细胞因子（包括转化生长因子β 1）的显著相关性。放射治疗前血浆IL-8水平较低的患者发生SRILL的风险可能会增加，进一步的研究是必要的，以确定IL-8是否会增加SRILL的风险。在前瞻性试验中，8个水平可预测SRILI，以及该标志物是否可用于确定患者是否适合剂量递增。(c)2005年爱思唯尔公司
Purpose: To analyze plasma cytokine profiles before the initiation of radiation therapy to define a cytokine phenotype that correlates with risk of developing symptomatic radiation-induced lung injury (SRILI).Methods and Materials: Symptomatic radiation-induced lung injury was evaluated in 55 patients (22 with SRILI and 33 without SRILI), according to modified National Cancer institute common toxicity criteria. These plasma samples were analyzed by the multiplex suspension bead array system (Bio-Rad Laboratories; Hercules, CA), which included the following cytokines: interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, IL-17, granulocyte/macrophage colony-stimulating factor, interferon-gamma, monocyte chemotactic protein 1, macrophage inflammatory protein 10, tumor necrosis factor alpha, and granulocyte colony-stimulating factor.Results: Significant differences in the median values of IL-8 were observed between patients with and without SRILI. Patients who did not develop SRILI had approximately fourfold elevated levels of IL-8 as compared with patients who did subsequently develop SRILL Significant correlations were not found for any other cytokine in this study, including transforming growth factor beta 1.Conclusions: Patients with lower levels of plasma IL-8 before radiation therapy might be at increased risk for developing SRILL Further studies are necessary to determine whether IL-8 levels are predictive of SRILI in a prospective trial and whether this marker might be used to determine patient eligibility for dose escalation. (c) 2005 Elsevier Inc.