Gas chromatography with state-of-the-art micromachined differential mobility detection: Operation and industrial applications
Gas chromatography with state-of-the-art micromachined differential mobility detection: Operation and industrial applications
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DOI：
10.1093/chromsci/44.5.276
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发表时间：
2006-05-01
影响因子：
1.3
通讯作者：
Cortes, Hernan
中科院分区：
文献类型：
--
作者：
Luong, Jim;Gras, Ronda;Cortes, Hernan
离子迁移谱（IMS）在化学、石油化工、环境以及最近的药物、化学战剂和爆炸物检测等非常不同的领域中具有潜在的分析应用。市售的IMS仪器基于飞行时间（TOF）质谱法。IMS本质上适合于现场操作，因为它使用相对简单的微流体装置并在大气压下操作。它是便携式的，具有可调选择性的高灵敏度，但可以以相对低的成本生产。这种分析检测技术的关键限制是低占空比、离子簇形成、短线性动态范围以及在单次分析中仅限于正离子或负离子收集。微机电系统，射频调制IMS（MEMS RF-IMS），也被称为差分迁移率光谱，最近已经开发和商业化。该技术基于IMS，MEMS RFIMS提供了更好的性能。在这项研究中，最近推出的差分迁移率检测器的优点和局限性时，与气相色谱痕量分析进行了讨论和说明与工业意义的应用。
Ion mobility spectrometry (IMS) has potential analytical applications in very diverse fields such as chemical, petrochemical, environmental, and, more recently, in drug, chemical warfare agent, and explosives detection. Commercially available IMS instruments are based on time-of-flight (TOF) mass spectrometry. IMS is inherently suitable for field operation as it uses relatively simple microfluidic devices and operates at atmospheric pressure. It is portable, highly sensitive with tunable selectivity, yet can be produced at relatively low cost. Key limitations of this analytical detection technique are low duty cycle, ion cluster formation, short linear dynamic range, and restriction to only positive or negative ion collection in a single analysis. Microelectromechanical system, radio frequency modulated IMS (MEMS RF-IMS), also known as differential mobility spectrometry, has recently been developed and commercialized. The technology is based on IMS, and MEMS RFIMS offers substantially better performance. In this study, the strengths and limitations of the recently introduced differential mobility detector when used with gas chromatography in trace analyses are discussed and illustrated with applications of industrial significance.