Isolation, Structure Determination, and Synthesis of Galaxamide, A Rare Cytotoxic Cyclic Pentapeptide from a Marine Algae Galaxaura filamentosa
Isolation, Structure Determination, and Synthesis of Galaxamide, A Rare Cytotoxic Cyclic Pentapeptide from a Marine Algae Galaxaura filamentosa
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DOI：
10.1021/ol801799d
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发表时间：
2008-10-16
期刊：
影响因子：
5.2
通讯作者：
Pan, Shan-Shan
中科院分区：
文献类型：
--
作者：
Xu, Wen-Jie;Liao, Xiao-Jian;Pan, Shan-Shan
Galaxamide（1）是从海藻Galaxaura filamentosa中分离得到的一种稀有环状五肽。Galaxamide对GRC-1和HepG（2）细胞株具有明显的体外抗增殖活性。首次实现了环肽的全合成，用于进一步的生物学评价。
Galaxamide (1), a rare cyclic pentapeptide, was isolated from the marine algae Galaxaura filamentosa. A preliminary bioassay of Galaxamide showed remarkable in vitro antiproliferative activities against GRC-1 and HepG(2) cell lines. The first total synthesis of the cyclic peptide was achieved for further biological evaluation.