Rh(I)‐Catalyzed Direct C6−H Arylation of 2‐Pyridones with Aryl Carboxylic Acids
Rh(I)‐Catalyzed Direct C6−H Arylation of 2‐Pyridones with Aryl Carboxylic Acids
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DOI：
10.1002/adsc.202100596
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发表时间：
2021-06
影响因子：
5.4
通讯作者：
Haoqiang Zhao;Jianbin Xu;Xin Xu;Yixiao Pan;Zexin Yu;Lijin Xu;Q. Fan;P. Walsh
中科院分区：
文献类型：
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作者：
Haoqiang Zhao;Jianbin Xu;Xin Xu;Yixiao Pan;Zexin Yu;Lijin Xu;Q. Fan;P. Walsh
开发了一种Rh（I）催化的2-吡啶酮与廉价、易得、安全且结构多样的芳基羧酸在吡啶导向基团的帮助下的C6-选择性C−H芳基化反应。该脱羰基芳基化方案具有易于处理的催化体系，并且适合于二取代的2-吡啶酮和芳基羧酸。它允许获得广泛的C6-芳基化2-吡啶酮，包括那些难以使用传统的C-H芳基化方法制备的化合物。该方法容许各种电子中性、富电子和缺电子官能团，并以41-91%的产率提供产物。
A Rh(I)‐catalyzed C6‐selective C−H arylation of 2‐pyridones with inexpensive, readily available, safe and structurally diverse aryl carboxylic acids with the aid of a pyridine directing group is developed. This decarbonylative arylation protocol features an easy‐to‐handle catalytic system, and is amenable to diversely substituted 2‐pyridones and aryl carboxylic acids. It allows access to a wide range of C6‐arylated 2‐pyridones, including those that are difficult to prepare using conventional C−H arylation processes. The method tolerates various electron‐neutral, electron‐rich and electron‐deficient functional groups, and affords the products in 41–91% yields.