Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age - The muscatine study
Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age - The muscatine study
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DOI：
10.1161/hc4601.099486
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发表时间：
2001-12-04
期刊：
影响因子：
37.8
通讯作者：
Lauer, RM
中科院分区：
文献类型：
--
作者：
Davis, PH;Dawson, JD;Lauer, RM
背景——较高的颈动脉内膜中层厚度（IMT）与心血管危险因素相关，并且可以预测老年人的冠状动脉疾病和中风。对年轻人和中年人进行了颈动脉 IMT 测量，以确定其与 (1) 儿童时期、(2) 当前和 (3) 作为从儿童到成年的“负荷”测量的危险因素的关系。 方法和结果 - 对年龄 33 至 42 岁的 346 名男性和 379 名女性进行了颈动脉超声研究，这些人是自童年起就跟踪的队列的代表，居住在爱荷华州马斯卡廷。确定每个受试者 12 个位置的最大颈动脉 IMT 测量值的平均值。完成了医学调查问卷，并获得了人体测量特征和危险因素的测量结果。男性平均最大颈动脉 IMT 为 0.79 +/-0.12 分钟，女性为 0.72 +/-0.10 毫米。根据多变量分析，当前 IMT 的重要预测因素是两性的年龄和 LDL 胆固醇以及女性的舒张压。总胆固醇对于男女来说都是重要的儿童期预测因子，而儿童期体重指数仅在女性中具有重要意义。对于男性来说，LDL 胆固醇、HDL 胆固醇和舒张压是危险因素负荷模型中颈动脉 IMT 的预测因素，而对于女性来说，LDL 胆固醇、体重指数和甘油三酯是预测因素。 结论：青壮年中较高的颈动脉 IMT 与儿童和当前心血管危险因素以及危险因素负荷相关。
Background-Higher carotid intimal-medial thickness (IMT) is associated with cardiovascular risk factors and is predictive of coronary artery disease and stroke in older adults. Carotid IMT was measured in young and middle-aged adults to determine its relationship with risk factors measured (1) in childhood, (2) currently, and (3) as a "load" from childhood to adulthood.Methods and Results-Carotid ultrasound studies were performed in 346 men and 379 women aged 33 to 42 years who were representative of a cohort followed since childhood and who live in Muscatine, Iowa. The mean of the measurements of maximal carotid IMT at 12 locations was determined for each subject. A medical questionnaire was completed, and measurements of anthropometric characteristics and risk factors were obtained. The mean maximum carotid IMT was 0.79 +/-0.12 min for men and 0.72 +/-0.10 mm for women. On the basis of multivariable analysis, the significant current predictors of IMT were age and LDL cholesterol in both sexes and diastolic blood pressure in women. Total cholesterol was a significant childhood predictor in both sexes, while childhood body mass index was significant only in women. For men, LDL cholesterol, HDL cholesterol, and diastolic blood pressure were predictive of carotid IMT in a risk factor load model, whereas in women, LDL cholesterol, body mass index, and triglycerides were predictive.Conclusions-Higher carotid IMT in young and middle-aged adults is associated with childhood and current cardiovascular risk factors, as well as risk factor load.