Lattice Boltzmann modelling of blood cell dynamics
Lattice Boltzmann modelling of blood cell dynamics
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DOI：
10.1080/10618560802238242
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发表时间：
2008-01-01
影响因子：
1.3
通讯作者：
Munn, L. L.
中科院分区：
文献类型：
--
作者：
Dupin, M. M.;Halliday, I.;Munn, L. L.
许多疾病都是由异常血流引起的，或者与异常血流有关。通常，这些异常是由形状改变的不健康红细胞引起的，这些红细胞难以穿过微血管。不幸的是，这些问题的实验方法是有限的，由于在体内或体外分离流动的关键决定因素的困难。计算机模型克服了这些问题，但大多数模型只是通过许多简化的假设来再现血液流动的宏观连续性方面。不幸的是，这些模型不能解决微观，细胞流动动力学和宏观，散装血液流变学之间的关系。在这里，我们展示了一个新的，计算模型，包括明确的每个血细胞模拟血流的广泛适用性。这个全3D模型考虑了细胞膜动力学，并准确地再现了静止的形状。这种模式使我们能够：（i）提取用于宏观模型的经验关系，以及（ii）模拟各种疾病状态以识别潜在的治疗靶点。我们在这里表明，该模型准确地再现了健康血液的良好记录的流动关系，并预测疟疾和镰状细胞患者表现出的血液流变学异常。
Many diseases are a result of, or are associated with, abnormal blood flow. Usually, these abnormalities are caused by unhealthy red blood cells with modified shape which have difficulty traversing the microvessels. Unfortunately, experimental approaches to these problems are limited due to difficulties in isolating the critical determinants of flow in vivo or in vitro. Computer models overcome these problems, but most strive only to reproduce the macroscopic, continuum aspect of blood flow by making many simplifying assumptions. Unfortunately, these models cannot address the relationship between microscopic, cellular flow dynamics and macroscopic, bulk blood rheology. Here, we demonstrate the wide applicability of a novel, computational model for simulating blood flow that includes each blood cell explicitly. This fully 3D model accounts for cell membrane dynamics and reproduces rest shapes accurately. This model allows us to: (i) extract empirical relationships for use in macroscopic models and (ii) simulate various disease states to identify potential targets for therapy. We show here that the model accurately reproduces the well-documented flow relationships for healthy blood, and also predicts the abnormalities in blood rheology exhibited by malaria and sickle cell patients.