Algorithm of Golgi protein 73 and liver stiffness accurately diagnoses significant fibrosis in chronic HBV infection
Algorithm of Golgi protein 73 and liver stiffness accurately diagnoses significant fibrosis in chronic HBV infection
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高尔基体蛋白 73 和肝脏硬度的算法可准确诊断慢性 HBV 感染的显着纤维化。
DOI：
10.1111/liv.13536
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发表时间：
2017-11-01
影响因子：
6.7
通讯作者：
Xie, Qing
中科院分区：
文献类型：
--
作者：
Cao, Zhujun;Li, Ziqiang;Xie, Qing
背景与目的血清高尔基体蛋白73（GP73）是评估纤维化的潜在生物标志物。我们的目的是开发一种基于GP73和肝硬度（LS）的算法，以进一步提高未经抗病毒治疗的慢性B型肝炎病毒（HBV）感染患者显著纤维化的准确性。结果在未经抗病毒治疗的慢性HBV感染患者中，观察到血清GP 73在纤维化阶段呈逐步增加的模式。血清GP73水平显著相关（rho= 0.48，P
Background & AimsSerum Golgi protein 73 (GP73) is a potential biomarker for fibrosis assessment. We aimed to develop an algorithm based on GP73 and liver stiffness (LS) for further improvement of accuracy for significant fibrosis in patients with antiviral-naive chronic hepatitis B virus (HBV) infection.MethodsDiagnostic accuracy evaluation of GP73 and development of GP73-LS algorithm was performed in training cohort (n=267) with an independent cohort (n=133) for validation.ResultsA stepwise increasing pattern of serum GP73 was observed across fibrosis stages in patients with antiviral-naive chronic HBV infection. Serum GP73 significantly correlated (rho=0.48, P