Targeting PDAC metabolism: Environment determines what has GOT2 give.
Targeting PDAC metabolism: Environment determines what has GOT2 give.
复制标题
针对 PDAC 代谢：环境决定 GOT2 的作用。
DOI：
10.1016/j.cmet.2022.09.027
复制
发表时间：
2022
期刊：
影响因子：
29
通讯作者：
Sullivan,LucasB
中科院分区：
文献类型：
--
作者：
Newsom,OliverJ;Sullivan,LucasB
代谢紊乱是癌症治疗的支柱，促使研究旨在确定新的代谢靶点。尽管在培养中观察到了强烈的影响，但最近的三项研究发现，胰腺肿瘤对代谢酶GOT2的破坏是难耐的，揭示了肿瘤微环境中绕过其传统代谢角色的复杂相互作用。
Metabolic disruption is a mainstay of cancer therapy, prompting research aimed at identifying novel metabolic targets. Despite strong effects observed in culture, three recent studies found pancreatic tumors are refractory to disruption of the metabolic enzyme GOT2, revealing complex interactions within the tumor microenvironment that bypass its conventional metabolic roles.