Sex-based differences in the longitudinal association between autistic traits and positive psychotic experiences in adolescents: A population-based cohort study
Sex-based differences in the longitudinal association between autistic traits and positive psychotic experiences in adolescents: A population-based cohort study
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DOI：
10.1016/j.schres.2022.05.027
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发表时间：
2022-06-10
影响因子：
4.5
通讯作者：
Kasai，Kiyoto
中科院分区：
文献类型：
--
作者：
Kiyono，Tomoki;Ando，Shuntaro;Kasai，Kiyoto
以前的报告表明，青少年的自闭症特征和精神病经历（PE）之间存在着横断面关联。然而，虽然自闭症特征和PE都显示出与性别相关的差异，但没有研究直接评估自闭症特征和PE之间的纵向关联是否存在这种差异。使用基于人口的青少年队列样本（n= 3007），我们测试了自闭症特征和积极PE之间的纵向关联是否受到性别差异的影响，使用回归分析。在12岁时（时间点1 [T1]）评估自闭症特征，并在12岁和14岁时（T1和T2）评估PE。随后，我们使用结构方程模型，在控制T1时的PE，社会经济状况，学校表现和父母的精神疾病后，测试自闭症特征的子领域（社交，沟通，想象力，注意细节和注意力转换的困难）是否与PE的亚型（幻听，幻视和妄想）相关。在控制了T1的PE后，我们没有发现T1的自闭症特征与T2的PE之间有任何联系。有没有显着的积极或消极的关联之间的所有子领域的自闭症特征和亚型的PE在两种性别。自闭症特征似乎并不能预测未来的PE一般青少年，无论性别。
Previous reports have suggested a cross-sectional association between autistic traits and psychotic experiences (PEs) in adolescents. However, while both autistic traits and PEs show sex-related differences, no studies have directly assessed whether such differences exist in the longitudinal association between autistic traits and PEs. Using a population-based adolescent cohort sample (n= 3007), we tested whether the longitudinal association between autistic traits and positive PEs was affected by sex-based differences using regression analyses. Autistic traits were assessed at 12 years old (timepoint 1 [T1]), and PEs were assessed at 12 and 14 years old (T1 and T2). Subsequently, we tested whether subdomains of autistic traits (difficulties in social interaction, communication, imagination, attention to detail, and attention switching) were associated with subtypes of PEs (auditory hallucinations, visual hallucinations, and delusions) using structural equation modeling, after controlling for PEs at T1, socio-economic status, school performance and parents' psychiatric disorders. After controlling for PEs at T1, we did not find any associations between autistic traits at T1 and PEs at T2 in both sexes. There was no significant positive or negative association between all subdomains of autistic traits and subtypes of PEs in both sexes. Autistic traits do not seem to predict future PEs in general adolescents regardless of sex.