Pilot trial of bacterial interference for preventing urinary tract infection
Pilot trial of bacterial interference for preventing urinary tract infection
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DOI：
10.1016/s0090-4295(01)01271-7
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发表时间：
2001-09-01
期刊：
影响因子：
2.1
通讯作者：
Hull, RA
中科院分区：
文献类型：
--
作者：
Darouiche, RO;Donovan, WH;Hull, RA
目标。探讨细菌干扰预防症状性尿路感染（UTI）的安全性和有效性。一项前瞻性，非随机，试点临床试验进行了脊髓损伤患者的神经源性膀胱和有症状性尿路感染频繁发作。患者膀胱接种非致病性大肠杆菌83972原型。将大肠杆菌83972定殖成功患者的症状性尿路感染率与(a)他们自己的基线研究前率和(b)未成功定殖患者的症状性尿路感染率进行比较。在44例接种患者中，30例（68%）感染大肠杆菌83972的时间为1个月或更长。在30例大肠杆菌83972定殖的患者中，仅发生了2例有症状的UTI发作（共34例患者-年），并且没有一例归因于大肠杆菌83972。与基线研究前相比，30名患者在大肠杆菌83972定植时，症状性尿路感染的发生率降低了63倍(平均0.06次/患者年，症状性尿路感染发生率为3.77次/患者年，P
Objectives. To examine the safety and efficacy of bacterial interference in preventing symptomatic urinary tract infection (UTI).Methods. A prospective, nonrandomized, pilot clinical trial was conducted in patients with spinal cord injury who had neurogenic bladder and had frequent episodes of symptomatic UTI. The bladder of patients was inoculated with a nonpathogenic prototype of Escherichia coli 83972. The rate of symptomatic UTI in successfully colonized patients while colonized with E. coli 83972 was compared with (a) their own baseline prestudy rate and (b) the rate of symptomatic UTI in patients who were not successfully colonized.Results. Of 44 inoculated patients, 30 (68%) became colonized with E. coli 83972 for 1 month or longer. Only two episodes of symptomatic UTI occurred in the group of 30 patients while colonized with E. coli 83972 (a total of 34 patient-years), and none was attributed to E. coli 83972. The group of 30 patients experienced a 63-fold reduction in the rate of symptomatic UTI while colonized with E. coli 83972 versus their baseline prestudy period (mean 0.06 versus 3.77 episodes of symptomatic UTI/patient-year, P