Differences between tuberculosis cases infected with Mycobacterium africanum, West African type 2, relative to Euro-American Mycobacterium tuberculosis: an update
Differences between tuberculosis cases infected with Mycobacterium africanum, West African type 2, relative to Euro-American Mycobacterium tuberculosis: an update
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DOI：
10.1111/j.1574-695x.2009.00628.x
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发表时间：
2010-02-01
影响因子：
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通讯作者：
Adegbola, Richard A.
中科院分区：
文献类型：
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作者：
de Jong, Bouke C.;Adetifa, Ifedayo;Adegbola, Richard A.
非洲分枝杆菌（MAF）是西非人类肺结核的常见病因。我们先前描述了290例患者MAF和结核分枝杆菌（MTB）之间的表型差异。在目前的分析中，我们比较了692例结核病患者感染的两个最常见的谱系内（MTB）复杂的发现在冈比亚，即MAF西非2型（39%的患病率）和欧美MTB（55%的患病率）。我们确定了这两种微生物感染之间的其他表型差异。MAF患者更有可能是老年人和艾滋病毒感染者。此外，尽管他们抱怨咳嗽的时间相同，但胸部X光检查显示他们的疾病更严重，而且更有可能严重营养不良。在该队列中，MAF的患病率在7年内没有显着变化。
Mycobacterium africanum (MAF) is a common cause of human pulmonary tuberculosis in West Africa. We previously described phenotypic differences between MAF and Mycobacterium tuberculosis (MTB) among 290 patients. In the present analysis, we compared 692 tuberculosis patients infected with the two most common lineages within the (MTB) complex found in the Gambia, namely MAF West African type 2 (39% prevalence) and Euro-American MTB (55% prevalence). We identified additional phenotypic differences between infections with these two organisms. MAF patients were more likely to be older and HIV infected. In addition, they had worse disease on chest X-ray, despite complaining of cough for an equal duration, and were more likely severely malnourished. In this cohort, the prevalence of MAF did not change significantly over a 7-year period.