Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes
Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes
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DOI：
10.1038/327383a0
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发表时间：
1987-06
期刊：
影响因子：
64.8
通讯作者：
D. Tautz;R. Lehmann;H. Schnürch;R. Schuh;E. Seifert;A. Kienlin;K. Jones;H. Jäckle
中科院分区：
文献类型：
--
作者：
D. Tautz;R. Lehmann;H. Schnürch;R. Schuh;E. Seifert;A. Kienlin;K. Jones;H. Jäckle
果蝇差距类片段化基因hunchback的DNA序列表明，它与第一个被分析的缺口基因Krüppel一样，编码一类DNA结合蛋白的典型指状基序蛋白。与克吕佩尔不同的是，驼背基因编码的是母体转录本，它沿着胚胎的纵轴沿着分级。这一点，连同其在合子中表达模式的其他特征，表明差距基因之间的专业化。
The DNA sequence of hunchback, aDrosophilasegmentation gene of the gap class, reveals that likeKrüppel, the first gap gene analysed, it encodes a protein with finger motifs typical of a class of DNA-binding proteins. UnlikeKrüppel, hunchback encodes a maternal transcript, which becomes graded along the longitudinal axis of the embyro. This, together with other features of its pattern of expression in the zygote, suggests specialization among the gap genes.