Identification of neutrophil subpopulations with monoclonal antibodies
Identification of neutrophil subpopulations with monoclonal antibodies
复制标题
用单克隆抗体鉴定中性粒细胞亚群
DOI：
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
G. Gartland
中科院分区：
文献类型：
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作者：
L. Clement;J. Lehmeyer;G. Gartland
通过杂交瘤技术已经产生了两种识别人类中性粒细胞亚群的单抗。被称为1B5和4D1的抗体分别与外周血粒细胞的平均百分比分别为57%和51%。识别的抗原似乎是中性粒细胞特异性的，因为这些抗体不与嗜酸性粒细胞、血小板、红细胞、单核细胞或非粘附性外周血单核细胞反应。虽然这些抗体识别的中性粒细胞亚群几乎相同(共含)，但识别的抗原决定因素似乎不同。这些抗中性粒细胞亚群的单抗可能有助于研究中性粒细胞之间的功能异质性，以及对正常和异常髓系分化的研究。
Two monoclonal antibodies have been produced by the hybridoma technique that recognize subpopulations of human neutrophils. The antibodies, termed 1B5 and 4D1, react with a mean percentage of 57% and 51% of peripheral blood granulocytes, respectively. The antigens recognized appear to be neutrophil specific in that these antibodies do not react with eosinophils, platelets, erythrocytes, monocytes, or nonadherent peripheral blood mononuclear cells. Although the neutrophil subpopulations recognized by these antibodies are nearly identical (coinclusive), the antigenic determinants recognized appear to be different. These monoclonal antibodies to neutrophil subpopulations may prove useful to studying functional heterogeneity among neutrophils as well as for investigations of normal and abnormal myeloid differentiation.
通过单克隆抗体 (HNK-1) 识别的人类 NK 和 K 细胞的分化抗原。
DOI：
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发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Abo,T;Balch,CM
通讯作者：
Balch,CM
DOI：
10.1073/pnas.77.11.6764
发表时间：
1980
影响因子：
11.1
作者：
Ugolini,V;Nunez,G;Smith,RG;Stastny,P;Capra,JD
通讯作者：
Capra,JD