Relationship of cervical ectopy to chlamydia infection in young women
Relationship of cervical ectopy to chlamydia infection in young women
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DOI：
10.1783/147118906776276440
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发表时间：
2006-04-01
影响因子：
--
通讯作者：
Foley, E
中科院分区：
文献类型：
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作者：
Lee, V;Tobin, JI;Foley, E
目的：生殖器沙眼衣原体感染是英国最常见的细菌性传播感染（STI）。包括多个性伴侣和不一致使用避孕套在内的行为，以及宫颈异位等生物学因素，都可能增加对性传播感染的易感性。宫颈异位被认为会增加衣原体感染的风险，因为柱状上皮暴露于潜在的感染性接种物中。本研究旨在确定衣原体在宫颈异位的年轻女性中是否更为普遍。方法：回顾性分析2003年5 - 7月在朴茨茅斯泌尿生殖医学诊所接受性传播感染筛查的16-24岁女性的临床记录。收集的信息包括宫颈宫外容的存在与否、吸烟习惯、避孕方法、前3个月内的性伴侣数量以及以前的性传播感染。采用宫颈拭子链位移扩增法诊断衣原体感染。结果：共有231名女性被纳入研究。平均年龄为19.8岁。在107名妇女中发现宫颈异位的证据。宫颈异位组衣原体感染检出率为37.4%(40/107)，宫颈未异位组为21.8%（27/124）。差异有统计学意义（p = 0.009）。即使考虑到混杂变量，其重要性仍然存在。结论：宫颈异位是年轻女性常见的生理过程。宫颈异位的识别应提醒临床医生注意生殖器衣原体感染的可能性。应在年轻人中提供衣原体的机会性筛查，以减少感染及其后遗症的流行。
Objective: Genital Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection (STI) in the UK. Behaviours including multiple sex partners and inconsistent condom use, and biological factors such as cervical ectopy, may increase susceptibility to STIs. Cervical ectopy is thought to increase risk of chlamyclia infection by exposing columnar epithelium to a potential infectious inoculum. This study aimed to determine whether chlamyclia was more prevalent in young women with cervical ectopy.Methods: Clinical notes of women aged 16-24 years attending the Portsmouth Genitourinary Medicine Clinic for an STI screen during the period May-July 2003 were reviewed retrospectively. Information collected included the presence or absence of cervical ectopy, smoking habits, methods of contraception, number of sexual partners in the previous 3 months, and previous STIs. Chlamydia infection was diagnosed by using strand displacement amplification on cervical swabs.Results: A total of 231 women were included in the study. The mean age was 19.8 years. Evidence of cervical ectopy was found in 107 women. Chlamydial infection was detected in 37.4% (40/107) of those women with cervical ectopy and 21.8% (27/124) in those without cervical ectopy. This difference was statistically significant (p = 0.009). The significance remained even when accounting for confounding variables.Conclusions: Cervical ectopy is a common physiological process in young women. Recognition of cervical ectopy should alert the clinician to the possibility of a genital chlamydia infection. Opportunistic screening for chlamyclia in young people should be offered to reduce the prevalence of infection and its sequelae.