Fractionation with x rays and neutrons in mice: response of skin and C 3 H mammary tumours.
Fractionation with x rays and neutrons in mice: response of skin and C 3 H mammary tumours.
复制标题
小鼠中 X 射线和中子的分级：皮肤和 C 3 H 乳腺肿瘤的反应。
DOI：
10.1259/0007-1285-45-532-237
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
K. Butler
中科院分区：
文献类型：
--
作者：
J. Fowler;J. Denekamp;A. Page;A. Begg;S. B. Field;K. Butler
摘要快中子治疗的有效性进行了测试，它不太可能显示出任何优势，相对于传统的X射线，即对小鼠乳腺肿瘤，其中含有耐辐射的缺氧细胞，但复氧后，大剂量的X射线后广泛。通过比较早期皮肤反应的程度与150天时评估的局部肿瘤控制的标准频率来评估治疗效果。在X射线照射后再氧化的预期最佳间隔下，给出了五个和九个分数的X射线或快中子。还使用了单次给药。在9天内给予5次X射线确实与任何一次分次中子治疗一样有效，它们彼此非常相似，但在18天内给予9次X射线的效果要差得多。这些结果表明，X射线可以像快中子一样有效，通过一个非常优化的选择分馏剂量和间隔。然而，为了让这个选择重新…
Abstract The effectiveness of fast neutron therapy was tested where it was unlikely to show any advantage relative to conventional X rays, i.e. on a mouse mammary tumour which contains radioresistant hypoxic cells, but which reoxygenates extensively after a large X-ray dose. The therapeutic effects were estimated by comparing the degree of early skin reaction associated with a standard frequency of local tumour control assessed at 150 days. Five and nine fractions of X rays or fast neutrons were given at the expected optimum spacing for re-oxygenation after X rays. Single doses were also used. Five fractions of X rays given in nine days were indeed found to be as effective as either of the fractionated neutron treatments, which were closely similar to each other, but nine fractions of X rays in 18 days were considerably less effective. These results suggest that X rays can be made as effective as fast neutrons, by a sharply optimal choice of fractionation dose and interval. However, to make this choice re...