Age-related Iron Deposition in the Basal Ganglia: Quantitative Analysis in Healthy Subjects
Age-related Iron Deposition in the Basal Ganglia: Quantitative Analysis in Healthy Subjects
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DOI：
10.1148/radiol.2522081399
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发表时间：
2009-07-01
期刊：
影响因子：
19.7
通讯作者：
Chiapparini, Luisa
中科院分区：
文献类型：
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作者：
Aquino, Domenico;Bizzi, Alberto;Chiapparini, Luisa
目的：为了确定不同年龄的健康志愿者的基底神经节中的铁积累值，使用T1加权磁共振（MR）图像的R2* 和原始信号强度测量值，由基于体素的弛豫测定法（VBR）支持，并将其与先前报道的尸检材料中发现的铁浓度进行比较。材料和方法：伦理委员会批准了这项研究，参与者或他们的父母提供了书面知情同意书。在1.5 T下检查了80例受试者（41例女性和39例男性受试者;年龄范围，1-80岁）。计算每例受试者的R2* 值。获得苍白球（GP）、壳核、尾状核、黑质（SN）和额叶白色物质（FWM）的R2* 与年龄的曲线。为了突出不同年龄段铁浓度的可能差异，应用了VBR。在T1加权快速低角度拍摄图像上估计信号强度值，并在每个核中绘制感兴趣区域。R2* 值也进行了比较，与铁浓度报告在尸检研究。进行统计学分析（t检验），P <0.05（FDR校正）的差异是显著的。VBR在第2个十年和随后的十年之间的比较中显示出豆状核的显著差异（P <0.05，校正）。与尸检结果相比，GP（R-2 = 0.64）、壳核（R-2 = 0.51）和SN（R-2 = 0.53）具有良好的相关系数。信号强度曲线类似的R2* curve.Conclusion：R2* 测量可以用来量化脑铁的积累，从而可以更好地评估与铁沉积相关的神经退行性疾病。
Purpose: To determine the values of iron accumulation in the basal ganglia of healthy volunteers of different ages with R2* and raw signal intensity measurements from T1-weighted magnetic resonance (MR) images, supported by voxel-based relaxometry (VBR), and to compare them with previously reported iron concentrations found in autopsy material.Materials and Methods: The ethics committee approved the study, and the participants or their parents gave written informed consent. Eighty subjects (41 female and 39 male subjects; age range, 1-80 years) were examined at 1.5 T. For each subject, R2* values were calculated. Curves for R2* versus age were obtained for globus pallidus ( GP), putamen, caudate nucleus, substantia nigra (SN), and frontal white matter (FWM). To highlight possible differences in iron concentration among the age decades, VBR was applied. Signal intensity values were estimated on T1-weighted fast low-angle shot images, and regions of interest were drawn in each nucleus. R2* values were also compared with iron concentrations reported in a postmortem study. Statistical analysis was performed (t test), and a difference with P < .05 (FDR corrected) was significant.Results: The curves for R2* versus age showed an exponential increase with increasing age in all the basal ganglia. VBR demonstrated significant differences ( P < .05, corrected) in the comparison between the 2nd and the following decades for lenticular nuclei. Good correlation coefficients were found for GP (R-2 = 0.64), putamen (R-2 = 0.51), and SN (R-2 = 0.53) when compared with findings in the postmortem study. Signal intensity curves were similar to the R2* curves.Conclusion: R2* measurements can be used to quantify brain iron accumulation and thus may allow better evaluation of neurodegenerative diseases associated with iron deposition.