Chronic and treatment-resistant depression: A study using arterial spin labeling perfusion MRI at 3 Tesla
Chronic and treatment-resistant depression: A study using arterial spin labeling perfusion MRI at 3 Tesla
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DOI：
10.1016/j.pscychresns.2010.01.009
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发表时间：
2010-05-30
影响因子：
2.3
通讯作者：
Drapier, Dominique
中科院分区：
文献类型：
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作者：
Duhameau, Berengere;Ferre, Jean-Christophe;Drapier, Dominique
本研究的目的是比较慢性难治性抑郁症患者与健康对照组，使用静息态灌注与动脉自旋标记（ASL）灌注磁共振成像（MRI）技术在3 T。这项研究集中在膝下前扣带皮层（sACC），这是抑郁症病理生理学的关键组成部分。ASL是一种创新的成像技术，它回避了其他功能性神经成像技术（功能性MRI，正电子发射断层扫描）的局限性。使用SPM 2软件对灌注图进行统计分析。与健康对照组相比，抑郁症患者组中存在统计学显著的高灌注区域。双侧sACC、左侧前额叶背内侧皮层、左侧ACC和左侧皮质下区（壳核、苍白球和杏仁核）。这项研究证实了sACC参与抑郁症，特别是慢性和难治性抑郁症，使用ASL在3 T，一个安全的灌注技术，似乎是适当的调查功能异常的精神疾病。(C)2010爱思唯尔爱尔兰有限公司版权所有
The aim of the present study was to compare patients displaying chronic and treatment-resistant depression with healthy controls, using the resting-state perfusion with arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) technique at 3 T. The study focused on the subgenual anterior cingulate cortex (sACC), which is a key component in the pathophysiology of depression. Six patients with chronic and treatment-resistant depression and six healthy control subjects were included ASL is an innovative imaging technique which sidesteps the limitations of other functional neuroimaging techniques (functional MRI, positron emission tomography). A statistical analysis of perfusion maps was performed using SPM2 software. Statistically significant hyperperfusion regions were found in the depressed patient group compared with the healthy control group in the following. the bilateral sACC, left prefrontal dorsomedian cortex, left ACC and left subcortical areas (putamen, pallidum and amygdala). This study confirmed the involvement of the sACC in depression, particularly chronic and treatment-resistant depression, using ASL at 3 T, a safe perfusion technique that seems to be appropriate for investigating functional abnormalities in psychiatric disorders. (C) 2010 Elsevier Ireland Ltd. All rights reserved