Modeling immune responses with handling time
Modeling immune responses with handling time
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DOI：
10.1006/bulm.2000.0181
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发表时间：
2000-09-01
影响因子：
3.5
通讯作者：
Antia, R
中科院分区：
文献类型：
--
作者：
Pilyugin, SS;Antia, R
简单的捕食者-猎物类型模型使人们对非特异性和抗原特异性免疫反应的动态有了更多的了解。然而，到目前为止，大多数注意力都集中在检查寄生虫和免疫系统之间相互作用的动态如何取决于描述免疫细胞响应寄生虫的激活或增殖速率的功能的性质。在本文中，我们重点关注描述细胞介导的免疫反应杀死寄生虫的术语。该术语之前被认为是一个简单的群体作用术语，仅依赖于寄生虫和免疫细胞的密度的乘积，并且没有考虑处理时间（我们将其定义为免疫细胞与其目标之间相互作用的时间，在此期间免疫细胞不能与其他目标相互作用和/或破坏其他目标）。我们展示了如何将处理时间（i）纳入非特异性和特异性免疫的简单模型中，以及（ii）它如何影响非特异性和抗原特异性免疫反应的动态，特别是免疫反应控制感染的能力。 (C) 2000 年数学生物学学会。
Simple predator-prey type models have brought much insight into the dynamics of both nonspecific and antigen-specific immune responses. However, until now most attention has been focused on examining how the dynamics of interactions between the parasite and the immune system depends on the nature of the function describing the rate of activation or proliferation of immune cells in response to the parasite. In this paper we focus on the term describing the killing of the parasite by cell-mediated immune responses. This term has previously been assumed to be a simple mass-action term dependent solely on the product of the densities of the parasite and the immune cells and does not take into account a handling time (which we define as the time of interaction between an immune cell and its target, during which the immune cell cannot interact with and/or destroy additional targets). We show how the handling time (i) can be incorporated into simple models of nonspecific and specific immunity and (ii) how it affects the dynamics of both nonspecific and antigen-specific immune responses, and in particular the ability of the immune response to control the infection. (C) 2000 Society for Mathematical Biology.