The Pediatric Critical Care Transfusion and Anemia Expertise Initiative Consensus Conference Methodology.
The Pediatric Critical Care Transfusion and Anemia Expertise Initiative Consensus Conference Methodology.
复制标题
儿科重症监护输血和贫血专业知识倡议共识会议方法。
DOI：
10.1097/pcc.0000000000001593
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
PediatricCriticalCareBloodResearchNetwork(BloodNet),
中科院分区：
文献类型：
--
作者：
Bembea,MelaniaM;Valentine,StaceyL;Bateman,ScotT;Wilson,LisaM;Anton,Blair;Harger,Nancy;Robinson,KarenA;PediatricCriticalCareTransfusionandAnemiaExpertiseInitiative(TAXI);PediatricCriticalCareBloodResearchNetwork(BloodNet),
目的：本文描述了儿科重症监护输血和贫血专家倡议共识会议所使用的方法。设计：儿科重症监护和输血医学国际专家的共识会议，遵循医学研究所制定的标准，使用研究与开发/加州大学洛杉矶分校适当性方法，仿照儿科急性肺损伤共识会议。与患有危重病或有患危重病风险的儿童红细胞输注相关的主题被分为九个亚组，并对文献进行了系统回顾。方法：由 38 名内容专家和 4 名方法学专家组成的小组在 2 年内召开了 3 次会议，合作制定基于证据的临床建议以及在缺乏证据时基于专家的临床建议以及危重病儿童或有危重病风险的儿童红细胞输血的研究重点。从 1980 年到 2017 年 5 月，使用 PubMed、Embase 和 Cochrane 图书馆数据库进行了电子检索。使用研究与开发/加州大学洛杉矶分校适当性方法获得了协议。我们使用标准化的数据提取形式构建证据表，并使用建议评估、制定和评估分级系统对证据进行分级。 主要结果：共识会议产生了 102 条推荐声明，其中 57 条是临床建议（20 条基于证据，37 条基于专家共识），45 条针对未来研究的详细建议。传播是通过决策树完成的，这是一份列出所有陈述的主要出版物，以及每个子主题的单独出版物，其中包括每项建议的支持论据。 结论：来自世界各地的专家共识会议制定了关于危重儿童或有危重疾病风险的儿童红细胞输血的建议，确定了当前的研究差距和未来的研究重点。
Objectives:This article describes the methodology used for Pediatric Critical Care Transfusion and Anemia Expertise Initiative Consensus Conference.Design:Consensus conference of international experts in pediatric critical care and transfusion medicine, following standards set by the Institute of Medicine, using the Research and Development/UCLA Appropriateness Method, modeled after the Pediatric Acute Lung Injury Consensus Conference. Topics related to RBC transfusion in children with or at risk for critical illness were divided into nine subgroups with a systematic review of the literature.Methods:The panel of 38 content and four methodology experts met three times over the course of 2 years and collaborated to develop evidence-based and, when evidence was lacking, expert-based clinical recommendations as well as research priorities for RBC transfusions in critically ill children or those at risk for critical illness. Electronic searches were conducted using PubMed, Embase, and Cochrane Library databases from 1980 to May 2017. Agreement was obtained using the Research and Development/UCLA Appropriateness Method. We used a standardized data extraction form to construct evidence tables and graded the evidence using the Grading of Recommendations Assessment, Development, and Evaluation system.Main Results:The consensus conference resulted in 102 recommendation statements, of which 57 were clinical (20 evidence based and 37 based on expert consensus) and 45 detailed recommendations for future research. Dissemination was done via decision tree, a primary publication listing all statements, and separate publications for each subtopic that include supporting arguments for each recommendation.Conclusions:A consensus conference of experts from around the world developed recommendations for RBC transfusions in critically ill children or children at risk for critical illness, the identification of current research gaps, and future research priorities.