Why Do Red Blood Cells Have Asymmetric Shapes Even in a Symmetric Flow?
Why Do Red Blood Cells Have Asymmetric Shapes Even in a Symmetric Flow?
复制标题
DOI：
10.1103/physrevlett.103.188101
复制
发表时间：
2009-10-30
影响因子：
8.6
通讯作者：
Misbah, Chaouqi
中科院分区：
文献类型：
--
作者：
Kaoui, Badr;Biros, George;Misbah, Chaouqi
了解为什么红细胞（RBC）在小血管中以不对称形状（拖鞋状）运动是血液循环研究中的一个长期难题。通过考虑囊泡（红细胞的模型系统），我们发现拖鞋形状的对称形状的稳定性损失的结果。结果表明，采用拖鞋的形状导致细胞和施加的流之间的速度差显着减少，从而提供更高的流动效率的红细胞。更高的膜刚度导致拖鞋形态的急剧变化，从而提供了一个潜在的诊断工具，细胞病理学。
Understanding why red blood cells (RBCs) move with an asymmetric shape (slipperlike shape) in small blood vessels is a long-standing puzzle in blood circulatory research. By considering a vesicle (a model system for RBCs), we discovered that the slipper shape results from a loss in stability of the symmetric shape. It is shown that the adoption of a slipper shape causes a significant decrease in the velocity difference between the cell and the imposed flow, thus providing higher flow efficiency for RBCs. Higher membrane rigidity leads to a dramatic change in the slipper morphology, thus offering a potential diagnostic tool for cell pathologies.