Distribution of organobrominated and organochlorinated contaminants in Belgian human adipose tissue
Distribution of organobrominated and organochlorinated contaminants in Belgian human adipose tissue
复制标题
DOI：
10.1006/enrs.2002.4334
复制
发表时间：
2002-03-01
影响因子：
8.3
通讯作者：
Schepens, P
中科院分区：
文献类型：
--
作者：
Covaci, A;de Boer, J;Schepens, P
我们已经测量了阻燃剂，多溴联苯醚（PBDEs）的水平，在20个最近的人体脂肪组织从比利时和比较其他有机卤素化合物，如多氯联苯（PCBs），六氯苯，2，2-双（4-氯苯基）-1，1，1-三氯乙烷（p，p '-DDT），及其代谢物，2，2-双（4-氯苯基）-1，1-二氯乙烯（p，p'-DBE）。在酸化硅胶固相萃取柱上进行索氏提取和净化后，通过毛细管气相色谱/电子轰击质谱法进行分析。该方法可测定5种多溴二苯醚和35种多氯联苯同系物。多溴联苯醚的浓度（国际化联编号28、47、99、100和153）介于2.2和11.7纳克/克脂重之间，处于欧洲国家报告的多溴二苯醚浓度的低端。多氯联苯（35种同系物）总量的中位值为841纳克/克脂重，范围为286至1802纳克/克脂重。滴滴涕总和的中位数（根据p，p '-DDE和p，p'-DDT计算）为290纳克/克脂重，范围为47至2802纳克/克脂重。PCBs总量与DDTs总量呈良好的相关性（r=0.77，P < 0.05），而与PBDEs总量的相关性较弱（r=0.56，P < 0.05）。
We have measured the levels of flame retardants, polybrominated diphenyl ethers (PBDEs), in 20 recent human adipose tissues from Belgium and compared them to other organohalogen compounds such as polychlorinated biphenyls (PCBs), hexachlorobenzene, 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (p,p'-DDT), and its metabolite, 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DBE). After Soxhlet extraction and cleanup on acidified silica solid-phase extraction cartridges, analysis was achieved by capillary gas chromatography/electron impact mass spectrometry. The method allowed the determination of 5 PBDE and 35 PCB congeners. Concentrations of PBDEs (sum of congeners IUPAC Nos. 28, 47, 99, 100, and 153) ranged between 2.2 and 11.7 ng/g lipid weight and were on the lower end of reported PBDE concentrations in European countries. The median value for the sum of PCBs (35 congeners) was 841 ng/g lipid weight and ranged from 286 to 1802 ng/g lipid weight. The median value for the sum of DDTs (calculated from p,p'-DDE and p,p'-DDT) was 290 ng/g lipid weight and ranged from 47 to 2802 ng/g lipid weight. The sum of PCBs showed a good correlation with the sum of DDTs (r=0.77, P < 0.05), while the correlation with the sum of PBDEs was weaker (r=0.56, P