Biodegradable polymeric nanospheres formed by temperature-induced phase transition in a mixture of poly(lactide-co-glycolide) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer.
Biodegradable polymeric nanospheres formed by temperature-induced phase transition in a mixture of poly(lactide-co-glycolide) and poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer.
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可生物降解的聚合物纳米球，由聚(丙交酯-乙交酯)和聚(环氧乙烷)-聚(环氧丙烷)-聚(环氧乙烷)三嵌段共聚物的混合物中的温度诱导相变形成。
DOI：
10.1021/bm020066h
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发表时间：
2002
影响因子：
6.2
通讯作者：
S. Yuk
中科院分区：
文献类型：
--
作者：
Ka Eul Lee;Byoungjae Kim;S. Yuk
聚（环氧乙烷）-聚（环氧丙烷）-聚（环氧乙烷）三嵌段共聚物（F-127）和PLGA（聚（丙交酯-共-乙交酯））的混合物在它们的相变温度以上形成液态，并且通过将温度降低到相变温度以下来诱导相分离状态。基于F-127与PLGA混合物的温度诱导相变行为，设计了一种制备载药PLGA纳米球的新方法，并通过测定载药量、包封率和药物释放模式对其进行了表征。紫杉醇作为一种有效的抗癌药物，被选为模型药物。
The mixture of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer(F-127) and PLGA (poly(lactide-co-gycolide)) forms a liquid state above their phase transition temperatures, and the phase-separated state is induced by decreasing the temperature below the phase transition temperature. On the basis of the temperature-induced phase transition behavior in the mixture of F-127 and PLGA, a novel method for the preparation of drug-loaded PLGA nanospheres was designed and characterized by measuring the loading amount, the encapsulation efficiency, and the drug release pattern. Paclitaxel, used as a potent anticancer drug, was selected as a model drug.