Chronic alteration of circadian rhythm is related to impaired lung function and immune response
Chronic alteration of circadian rhythm is related to impaired lung function and immune response
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DOI：
10.1111/ijcp.13590
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发表时间：
2020-10-01
影响因子：
2.6
通讯作者：
Vieira, Rodolfo P.
中科院分区：
文献类型：
--
作者：
Aquino-Santos, Helida C.;Tavares-Vasconcelos, Jeanne S.;Vieira, Rodolfo P.
昼夜节律的改变对健康的几个方面产生负面影响，包括肺功能。慢性轮班量表经典诱导昼夜节律的改变。然而，其对肺免疫应答的影响尚不清楚。目的探讨慢性昼夜节律改变对肺功能和免疫功能的影响。方法采用12 × 24小时和12 × 48小时工作量表对轮班制警察进行调查，（n = 25; 38.73 ± 6.92岁）与固定工作量（8 h/d）的文职人员进行了比较（n = 25; 34.00 +/- 9.60岁），对他们的感知压力、嗜睡、身体活动水平、人体测量特征、肺功能，肺和全身的细胞和体液免疫应答。结果与普通男性相比，警察的压力感知水平（P <0.0008）、嗜睡程度（P <0.04）和肺功能（用力肺活量（FVC）和第一秒用力呼气量（FEV 1）降低（P <0.053和P <0.043）明显升高。此外，呼出气中一氧化氮（P <0.037）和呼出气冷凝液中IL-2（P <0.0046）水平的升高表明，与普通男性相比，警察存在慢性肺部炎症。尽管全血分析没有显示两组之间关于白细胞数量的任何差异，但体液反应显示警察呈现出IL-2水平升高（P <0.002）和IL-10水平降低（P <0.001），清楚地显示出低度炎症的临床状态。结论轮班警察慢性昼夜节律改变不仅导致肺功能损害，而且还损害肺和全身免疫功能。
Background Alterations of the circadian rhythm negatively impact several aspects of the health, including the lung function. Chronic shiftwork scale classically induces alterations in the circadian rhythm. However, its effects on pulmonary immune response are unknown. Aims To evaluate the impact of chronic alteration of circadian rhythm on pulmonary function and immune response. Methods In this context, a 12 x 24 hours and 12 x 48 hours work scale in shiftwork scale policemen (n = 25; 38.73 +/- 6.92 years old) were compared with fixed work scale (8 h/d) civil men (n = 25; 34.00 +/- 9.60 years old) who were evaluated for perceived stress, sleepiness, physical activity levels, anthropometric characteristics, lung function, pulmonary and systemic cellular and humoral immune response. Results Policemen presented increased levels of perceived stress (P < .0008), impaired sleepiness (P < .04) and lung function as demonstrated by reduced forced vital capacity (FVC) (P < .053) and FEV1 (P < .043) when compared with civil men. In addition, increased levels of exhaled nitric oxide (P < .037) and of IL-2 (P < .0046) in the breath condensate revealed that policemen presented chronic lung inflammation compared with civil men. Although the whole blood analysis did not showed any differences between the two groups concerning the number of leucocytes, the humoral response revealed that policemen presented increased levels of IL-2 (P < .002) and lower levels of IL-10 (P < .001), clearly displaying a clinical status of low-grade inflammation. Conclusions Chronic alteration of circadian rhythm in shiftwork scale policemen results in impaired lung function, beyond to impair pulmonary and systemic immune function.