PAK1 as a therapeutic target.
PAK1 as a therapeutic target.
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PAK1作为治疗靶标。
DOI：
10.1517/14728222.2010.492779
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发表时间：
2010-07
影响因子：
5.8
通讯作者：
Kandel ES
中科院分区：
文献类型：
--
作者：
Kichina JV;Goc A;Al-Husein B;Somanath PR;Kandel ES
P21-activated kinases (PAKs) are involved in multiple signal transduction pathways in mammalian cells. PAKs, and PAK1 in particular, play a role in such disorders as cancer, mental retardation and allergy. Cell motility, survival and proliferation, the organization and function of cytoskeleton and extracellular matrix, transcription and translation are among the processes affected by PAK1. We discuss the mechanisms that control PAK1 activity; its involvement in physiological and pathophysiological processes; the benefits and the drawbacks of the current tools to regulate PAK1 activity; the evidences that point to PAK1 as a therapeutic target; and the likely directions of future research. The reader will gain a better knowledge and understanding of the areas covered in this review. PAK1 is a promising therapeutic target in cancer and allergen-induced disorders. Its suitability as a target in vascular, neurological and infectious diseases remains ambiguous. Further advancement of this field requires progress on such issues as the development of specific and clinically acceptable inhibitors, the choice between targeting one or multiple PAK isoforms, elucidation of the individual roles of PAK1 targets and the mechanisms that may circumvent inhibition of PAK1.
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影响因子：
9.2
作者：
Abraham, Sabu;Yeo, Margaret;Mavria, Georgia
通讯作者：
Mavria, Georgia
影响因子：
11.4
作者：
Abo, A;Qu, J;Minden, A
通讯作者：
Minden, A
影响因子：
5.3
作者：
Boda, B;Alberi, S;Muller, D
通讯作者：
Muller, D
DOI：
10.1016/j.biocel.2006.11.011
发表时间：
2007-01-01
影响因子：
4
作者：
Bernard, Ora
通讯作者：
Bernard, Ora
影响因子：
4.8
作者：
Alberts, AS;Qin, HJ;Frost, JA
通讯作者：
Frost, JA