ABNORMAL GLUCOSE-TOLERANCE DURING PREGNANCY IN PIMA INDIAN WOMEN - LONG-TERM EFFECTS ON OFFSPRING
ABNORMAL GLUCOSE-TOLERANCE DURING PREGNANCY IN PIMA INDIAN WOMEN - LONG-TERM EFFECTS ON OFFSPRING
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DOI：
10.2337/diab.40.2.s126
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发表时间：
1991-12-01
期刊：
影响因子：
7.7
通讯作者：
KNOWLER, WC
中科院分区：
文献类型：
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作者：
PETTITT, DJ;BENNETT, PH;KNOWLER, WC
在552名5-24岁的皮马印第安后代中检查了妊娠期间检测到的糖耐量异常对后代的长期影响。 空腹高胰岛素血症可能反映了胰岛素抵抗的增加，在怀孕期间糖耐量异常的女性的后代中发生在更早的年龄，这些后代更肥胖，糖耐量异常的发生率更高。 当控制混杂因素时，妊娠期2小时后血糖浓度升高1 mM导致后代糖尿病患病率显著升高（比值比= 1.62）。 母亲在怀孕期间的2小时葡萄糖浓度也是一个显着的预测葡萄糖浓度在怀孕期间的后代（P = 0.011）。 因此，与糖尿病妊娠相关的代谢异常会对后代产生长期影响，包括胰岛素抵抗、肥胖和糖尿病，这反过来又可能导致下一代发生相同问题的风险传递。
The long-term effects on offspring of abnormal glucose tolerance detected during pregnancy were examined in 552 Pima indian offspring 5-24 yr of age. Fasting hyperinsulinemia, presumably reflecting increased insulin resistance, occurred at an earlier age in the offspring of women who had abnormal glucose tolerance during pregnancy, and these offspring were more obese and had higher rates of abnormal glucose tolerance. When confounding factors were controlled, a 1 mM higher 2-h postload glucose concentration during pregnancy resulted in a significantly higher prevalence of diabetes in the offspring (odds ratio = 1.62). Maternal 2-h glucose concentration during pregnancy was also a significant predictor of glucose concentration during pregnancy in the offspring (P = 0.011). Thus, the metabolic abnormalities associated with the diabetic pregnancy result in long-term effects on the offspring, including insulin resistance, obesity, and diabetes, which in turn may contribute to transmission of risk for developing the same problems in the next generation.