Genome of the host-cell transforming parasite Theileria annulata compared with T-parva
Genome of the host-cell transforming parasite Theileria annulata compared with T-parva
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DOI：
10.1126/science.1110418
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发表时间：
2005-07-01
期刊：
影响因子：
56.9
通讯作者：
Hall, N
中科院分区：
文献类型：
--
作者：
Pain, A;Renauld, H;Hall, N
环芽孢杆菌和细小绦虫是引起牛淋巴细胞增生性疾病的密切相关的原生动物寄生虫。我们对环状虫的基因组进行了测序，并将其与细小虫的基因组进行了比较，以了解其转化和趋向性的机制。尽管基因序列和同源性高度保守，但分析显示基因家族和物种特异性基因扩展不均。我们还鉴定了可能降低免疫识别的推定分泌多肽的不同家族，宿主细胞转化的候选调节因子，以及存在于大量分泌蛋白中的梭菌特异性蛋白结构域[经常与梭菌（FAINT）相关]。
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.