Elevated circulating levels of IL-6 in schizophrenia
Elevated circulating levels of IL-6 in schizophrenia
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DOI：
10.1016/0920-9964(96)00014-x
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发表时间：
1996-07-05
影响因子：
4.5
通讯作者：
Dassa, D
中科院分区：
文献类型：
--
作者：
Naudin, J;Mege, JL;Dassa, D
精神分裂症可能是由细胞因子介导的免疫或炎症性疾病引起的。这方面的数据参差不齐，而且往往相互矛盾。我们研究了IL-6和TNF-α的循环水平，这两种不同的促炎细胞因子。采用免疫分析法检测了30例慢性精神分裂症患者和15例正常对照者血清中IL-6和TNF-α的水平。患者的IL-6循环水平高于对照组; TNF-α的循环水平并不显著高于对照组。此外，精神分裂症急性发作期患者的IL-6水平高于缓解期患者。我们的研究结果表明，精神分裂症的免疫异常可能与IL-6介导的特定炎症过程有关。一个有趣的研究方向是评价CSF中IL-6的脑产生。
Schizophrenia may result from immune or inflammatory disorders, which are mediated by cytokines. Data in this held are heterogeneous and often contradictory. We investigated circulating levels of IL-6 and TNF-alpha, two distinct proinflammatory cytokines. Using immunoassay, we assessed IL-6 and TNF-alpha in serum from chronic schizophrenic patients (n=30) and normal controls (n=15). Circulating levels of IL-6 were higher in patients than in controls; those of TNF-alpha were not significantly higher than in controls. In addition, IL-6 levels were higher in patients with acute exacerbation of schizophrenia than in patients with remissions. Our results suggest that immunologic abnormalities in schizophrenia may be related to a specific inflammatory process mediated by IL-6. An interesting line of research would be the evaluation of IL-6 cerebral production in CSF.