Incidence of HIV Infection in Young Gay, Bisexual, and Other YMSM: The P18 Cohort Study.
Incidence of HIV Infection in Young Gay, Bisexual, and Other YMSM: The P18 Cohort Study.
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DOI：
10.1097/qai.0000000000000616
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发表时间：
2015-08-01
期刊：
影响因子：
--
通讯作者：
Ompad D
中科院分区：
文献类型：
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作者：
Halkitis P;Kapadia F;Ompad D
新一代青年、男同性恋者、双性恋者和其他男男性行为者（YMSM）的艾滋病毒感染率继续上升，尽管三十年来一直在预防艾滋病毒，最近也有生物医学技术来阻止感染。研究HIV的发病率以及与偶发感染相关的人口统计学、行为和结构因素。队列研究。600名YMSM，基线时年龄为18-19岁。在基线时，检测到6例艾滋病毒流行病例。在36个月和另外6波数据收集的过程中，我们确定了43例（7.2%）艾滋病毒感染病例。居住在艾滋病毒流行率较高的社区的人的感染率略高。使用考克斯比例风险模型，我们发现黑人YMSM的HIV血清转换时间的风险比显著更高（HR = 7.46）和混合/其他种族YMSM（HR = 7.99），与另一名男子首次发生性行为时年龄较大与HIV血清转换风险较低相关（HR = 0.50），而低感知的家庭SES与HIV血清转换的风险增加略有相关（HR = 2.45）。这些研究结果支持艾滋病毒的差异，存在于人口中的性少数男性，并建议我们参加的行为，结构和社会条件，以有效地调整艾滋病毒预防新一代的YMSM与敏锐的眼睛所面临的条件种族和少数民族YMSM，提高他们获得艾滋病毒的风险。
HIV infections continue to rise in a new generation of young, gay, bisexual and other men who have sex with men (YMSM) despite three decades of HIV prevention and recent biomedical technologies to deter infection. To examine the incidence of HIV and the demographics, behavioral, and structural factors associated with incident infections. Cohort study. 600 YMSM who were ages 18-19 at baseline. At baseline 6 prevalent cases of HIV were detected. Over the course of 36 months and six additional waves of data collection, we identified 43 (7.2%) incident cases of HIV. Incident infections were marginally higher among those residing in neighborhoods with higher rates of HIV prevalence. Using Cox proportional hazards models we detected that hazard ratios for time to HIV seroconversion were significantly higher for Black YMSM (HR = 7.46) and Mixed/Other race YMSM (HR = 7.99), and older age at sexual debut with another man was associated with a lower risk of HIV seroconversion (HR = 0.50), while low perceived familial SES was marginally associated with an increased risk for HIV seroconversion (HR = 2.45). These findings support the disparities for HIV that exist within the population of sexual minority men and suggest that we attend to behavioral, structural and social conditions to effectively tailor HIV prevention for a new generation of YMSM with a keen eyes to the conditions faced by racial and ethnic minority YMSM which heightened their risk for acquiring HIV.