Clinical significance of atrophy and white matter mean diffusivity within the thalamus of multiple sclerosis patients
Clinical significance of atrophy and white matter mean diffusivity within the thalamus of multiple sclerosis patients
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DOI：
10.1177/1352458513478675
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发表时间：
2013-10-01
影响因子：
5.8
通讯作者：
Zivadinov, Robert
中科院分区：
文献类型：
--
作者：
Benedict, Ralph H. B.;Hulst, Hanneke E.;Zivadinov, Robert
背景：灰质（GM）萎缩是多发性硬化（MS）患者认知功能障碍的强预测因素。丘脑是萎缩/认知相关性最强的区域。然而，很少有研究评估扩散张量成像（DTI）的指标thalass.Objective：本研究旨在确定是否丘脑白色物质DTI预测认知功能障碍后占体积loss.Methods的影响：我们招募了75 MS患者和18名健康对照进行3 T脑磁共振成像（MRI）。在3DT 1图像上计算丘脑体积。在丘脑白色物质束内进行DTI度量的体素分析。神经心理学（NP）测试，采用共识标准方法获得，有助于记忆，认知处理速度和执行功能的测量。
Background: Gray-matter (GM) atrophy is strongly predictive of cognitive impairment in multiple sclerosis (MS) patients. The thalamus is the region where the atrophy/cognition correlation is most robust. However, few studies have assessed diffusion tensor imaging (DTI) metrics within the thalamus.Objective: This study was designed to determine if thalamus white matter DTI predicts cognitive impairment after accounting for the effects of volume loss.Methods: We enrolled 75 MS patients and 18 healthy controls undergoing 3T brain magnetic resonance imaging (MRI). Thalamus volumes were calculated on 3D T1 images. Voxelwise analyses of DTI metrics were performed within the thalamic white matter tracts. Neuropsychological (NP) testing, acquired using consensus standard methods, contributed measures of memory, cognitive processing speed and executive function.Results: All cognitive tests were significantly predicted (R-2 =0.31, p