BIOMATERIAL-CENTERED INFECTION - MICROBIAL ADHESION VERSUS TISSUE INTEGRATION
BIOMATERIAL-CENTERED INFECTION - MICROBIAL ADHESION VERSUS TISSUE INTEGRATION
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DOI：
10.1126/science.3629258
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发表时间：
1987-09-25
期刊：
影响因子：
56.9
通讯作者：
GRISTINA, AG
中科院分区：
文献类型：
--
作者：
GRISTINA, AG
生物材料正越来越频繁地用于组织替代。诸如全关节置换和全人工心脏的复杂装置代表用于系统和器官置换的聚合物和金属合金的组合。这些器械扩展使用的主要障碍是细菌粘附到生物材料上的可能性，这会导致以生物材料为中心的感染，以及缺乏成功的组织整合或与生物材料表面的相容性。生物材料与细菌和组织细胞的相互作用不仅由细胞表面上的特异性受体和外膜分子指导，而且还由生物材料表面的原子几何形状和电子状态指导。对这些机制的理解对医学的所有领域都很重要，并且与微生物学，生物化学和物理学的研究有关。在原子水平上对生物材料表面的修饰将允许细胞-基质事件的编程，从而通过增强组织相容性或整合或通过直接抑制细菌粘附来减少感染。
Biomaterials are being used with increasing frequency for tissue substitution. Complex devices such as total joint replacements and the total artificial heart represent combinations of polymers and metal alloys for system and organ replacement. The major barriers to the extended use of these devices are the possibility of bacterial adhesion to biomaterials, which causes biomaterial-centered infection, and the lack of successful tissue integration or compatibility with biomaterial surfaces. Interactions of biomaterials with bacteria and tissue cells are directed not only by specific receptors and outer membrane molecules on the cell surface, but also by the atomic geometry and electronic state of the biomaterial surface. An understanding of these mechanisms is important to all fields of medicine and is derived from and relevant to studies in microbiology, biochemistry, and physics. Modifications to biomaterial surfaces at an atomic level will allow the programming of cell-to-substratum events, thereby diminishing infection by enhancing tissue compatibility or integration, or by directly inhibiting bacterial adhesion.