Harnessing Thin-Film Continuous-Flow Assembly Lines
Harnessing Thin-Film Continuous-Flow Assembly Lines
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DOI：
10.1002/chem.201602373
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发表时间：
2016-07-25
影响因子：
4.3
通讯作者：
Raston, Colin L.
中科院分区：
文献类型：
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作者：
Britton, Joshua;Castle, Jared W.;Raston, Colin L.
受自然界通过连续合成转化构建复杂分子的能力的启发，开发了α-氨基膦酸酯的装配线合成。在这种方法中，简单的起始材料连续进料通过薄膜反应器，其中中间体随着它们通过流动系统的进展而产生分子复杂性。流动化学允许通过反应区室化发生快速的多步转化，这是一种不适合使用传统烧瓶的方法。薄膜加工还可以获得容易的原位溶剂交换以驱动反应效率，并且通过这种方法，α-氨基膦酸酯合成仅需要443 s的停留时间来产生3.22 g h（-1）。装配线合成允许前所未有的反应灵活性和加工效率。
Inspired by nature's ability to construct complex molecules through sequential synthetic transformations, an assembly line synthesis of alpha-aminophosphonates has been developed. In this approach, simple starting materials are continuously fed through a thin-film reactor where the intermediates accrue molecular complexity as they progress through the flow system. Flow chemistry allows rapid multistep transformations to occur via reaction compartmentalization, an approach not amenable to using conventional flasks. Thin film processing can also access facile in situ solvent exchange to drive reaction efficiency, and through this method, alpha-aminophosphonate synthesis requires only 443 s residence time to produce 3.22 g h(-1). Assembly-line synthesis allows unprecedented reaction flexibility and processing efficiency.