Stimulus Driven Single Unit Activity From Micro-Electrocorticography
Stimulus Driven Single Unit Activity From Micro-Electrocorticography
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DOI：
10.3389/fnins.2020.00055
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发表时间：
2020-02-28
影响因子：
4.3
通讯作者：
Gilja, Vikash
中科院分区：
文献类型：
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作者：
Hermiz, John;Hossain, Lorraine;Gilja, Vikash
对神经活动的高保真测量可以促进我们对言语、听力和语言等复杂行为的神经基础的理解，并且对于开发解决这些能力因疾病或伤害而受损的神经假体至关重要。我们开发了一种新型的高分辨率、薄膜微皮质脑电图仪(Micro-ECoG)阵列，可以高保真地测量鸣禽的神经活动，鸣禽是研究言语行为的成熟动物模型。有了这个装置，我们首次展示了表面记录的单一单位反应的感觉诱发调制。我们在麻醉的欧洲八哥上建立了在感觉运动核HVC(用作专有名称)表面的微型ECoG电极上一致地感觉到单个单位活动，并用同时在表面和深度记录的单个单位的相关放电来验证反应。这些结果建立了一个从皮质下结构表面进行高保真记录的平台，这将加速神经生理学研究，以及新型电极阵列和神经假体的开发。
High-fidelity measurements of neural activity can enable advancements in our understanding of the neural basis of complex behaviors such as speech, audition, and language, and are critical for developing neural prostheses that address impairments to these abilities due to disease or injury. We develop a novel high resolution, thin-film micro-electrocorticography (micro-ECoG) array that enables high-fidelity surface measurements of neural activity from songbirds, a well-established animal model for studying speech behavior. With this device, we provide the first demonstration of sensory-evoked modulation of surface-recorded single unit responses. We establish that single unit activity is consistently sensed from micro-ECoG electrodes over the surface of sensorimotor nucleus HVC (used as a proper name) in anesthetized European starlings, and validate responses with correlated firing in single units recorded simultaneously at surface and depth. The results establish a platform for high-fidelity recording from the surface of subcortical structures that will accelerate neurophysiological studies, and development of novel electrode arrays and neural prostheses.