Anal HPV infection in Slovenian men who have sex with men
Anal HPV infection in Slovenian men who have sex with men
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DOI：
10.2478/s11536-010-0019-4
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发表时间：
2010-12-01
影响因子：
--
通讯作者：
Mlakar, Bostjan
中科院分区：
文献类型：
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作者：
Milosevic, Milos;Poljak, Mario;Mlakar, Bostjan
肛门人类乳头瘤病毒（HPV）感染通常影响男男性行为者（MSM），并与肛门癌的发展有关，在人类免疫缺陷病毒（HIV）阳性的男男性行为者中患病率最高。本研究的目的是确定斯洛文尼亚男男性接触者肛门HPV感染的患病率和基因型分布及其与行为模式的相关性，以预测四价HPV疫苗在该人群中的可能影响。据我们所知，这是首次对东欧国家男男性接触者肛门HPV感染的患病率和基因型分布进行研究。这项研究包括136名从2007年1月到2008年12月到两个门诊就诊的男男性接触者。所有参与者都进行了临床检查和艾滋病毒检测，并采取肛门拭子进行HPV检测。结果显示，艾滋病毒阴性（75%）和艾滋病毒阳性（95%）的MSM肛门HPV感染的患病率都很高。滥交和使用“poppers”（通过直接吸入用于娱乐目的的烷基亚硝酸盐）显然与肛门HPV感染的较高患病率有关。四种最常见的HPV基因型分别是6、11、16和18。与其他研究相比，斯洛文尼亚MSM中肛门HPV感染的患病率更高。四价HPV疫苗在这一人群中可能有很大的潜力。
Anal human papillomavirus (HPV) infection commonly affects men who have sex with men (MSM) and is associated with the development of anal cancer, with the highest prevalence in MSM who are positive for human immunodeficiency virus (HIV). The purpose of this study was to determine the prevalence of anal HPV infection and genotype distribution in Slovenian MSM and its correlation with behavioral patterns in order to predict the possible impact of quadrivalent HPV vaccine in this population. To our knowledge, this is the first study of prevalence and genotype distribution of anal HPV infection in MSM from any of the Eastern European countries. The study included 136 MSM who visited two outpatient offices from January 2007 through December 2008. All participants were clinically examined and tested for HIV, and anal swabs were taken for HPV testing. The results showed a high prevalence of anal HPV infection in both HIV-negative (75%) and HIV-positive (95%) MSM. Promiscuity and use of "poppers" (alkyl nitrites taken for recreational purposes through direct inhalation) were clearly associated with a higher prevalence of anal HPV infection. The four most common HPV genotypes were 6, 11, 16, and 18. The prevalence of anal HPV infection in Slovenian MSM is higher in comparison with other studies. Quadrivalent HPV vaccine could have great potential in this population.