Risk factors for delayed viral suppression on first-line antiretroviral therapy among persons living with HIV in Haiti, 2013-2017.
Risk factors for delayed viral suppression on first-line antiretroviral therapy among persons living with HIV in Haiti, 2013-2017.
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DOI：
10.1371/journal.pone.0240817
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Delcher C
中科院分区：
文献类型：
--
作者：
Rich SN;Cook RL;Yaghjyan L;Francois K;Puttkammer N;Robin E;Bae J;Joseph N;Pessoa-Brandão L;Delcher C
在海地，对艾滋病毒感染者进行一线抗逆转录病毒治疗的病毒抑制研究有限，特别是在首都太子港所在的西部省以外的艾滋病毒感染者中。这项研究描述了2013年至2017年期间海地所有地理部门艾滋病毒感染者延迟病毒抑制的患病率和风险因素。包括在ART开始后3至12个月接受病毒载量检测的个体。人口统计学和临床护理数据来自海地艾滋病毒主动纵向跟踪数据库。进行多变量逻辑回归以预测延迟性病毒抑制，延迟性病毒抑制定义为至少3个月的抗逆转录病毒治疗后病毒载量≥1000 HIV-1 RNA拷贝/mL。可获得3，368例新开始抗逆转录病毒治疗的艾滋病毒感染者的病毒载量检测结果。延迟性病毒抑制的患病率为40%，略高于海地先前的估计。在多变量分析中，延迟的病毒抑制与年龄较小、在Ouest部门接受治疗、接受拉米夫定（3 TC）、齐多夫定（AZT）和奈韦拉平（NVP）联合ART方案治疗以及CD 4计数低于200个细胞/mm 3显著相关。总之，这项研究是第一个描述和比较延迟病毒抑制之间的差异在海地的地理部门艾滋病毒感染者。我们确定了公共卫生干预的目标人群，如更频繁的病毒载量检测，耐药性检测和ART依从性咨询。
Studies of viral suppression on first-line antiretroviral therapy (ART) in persons living with human immunodeficiency virus (PLHIV) in Haiti are limited, particularly among PLHIV outside of the Ouest department, where the capital Port-au-Prince is located. This study described the prevalence and risk factors for delayed viral suppression among PLHIV in all geographic departments of Haiti between 2013 and 2017. Individuals who received viral load testing 3 to 12 months after ART initiation were included. Data on demographics and clinical care were obtained from the Haitian Active Longitudinal Tracking of HIV database. Multivariable logistic regression was performed to predict delayed viral suppression, defined as a viral load ≥1000 HIV-1 RNA copies/mL after at least 3 months on ART. Viral load test results were available for 3,368 PLHIV newly-initiated on ART. Prevalence of delayed viral suppression was 40%, which is slightly higher than previous estimates in Haiti. In the multivariable analysis, delayed viral suppression was significantly associated with younger age, receiving of care in the Ouest department, treatment with lamivudine (3TC), zidovudine (AZT), and nevirapine (NVP) combined ART regimen, and CD4 counts below 200 cells/mm3. In conclusion, this study was the first to describe and compare differences in delayed viral suppression among PLHIV by geographic department in Haiti. We identified populations to whom public health interventions, such as more frequent viral load testing, drug resistance testing, and ART adherence counseling should be targeted.
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影响因子：
3.7
作者：
Velen K;Lewis JJ;Charalambous S;Grant AD;Churchyard GJ;Hoffmann CJ
通讯作者：
Hoffmann CJ
影响因子：
3.7
作者：
Smit PW;Sollis KA;Fiscus S;Ford N;Vitoria M;Essajee S;Barnett D;Cheng B;Crowe SM;Denny T;Landay A;Stevens W;Habiyambere V;Perriens JH;Peeling RW
通讯作者：
Peeling RW
影响因子：
4.1
作者：
Lynen, Lutgarde;Van Griensven, Johan;Elliott, Julian
通讯作者：
Elliott, Julian
影响因子：
5.2
作者：
Ruperez, Maria;Pou, Christian;Paredes, Roger
通讯作者：
Paredes, Roger
影响因子：
2.2
作者：
Ayele, Teshale;Jarso, Habtemu;Mamo, Girma
通讯作者：
Mamo, Girma