Molecular epidemiology of rabies in Indonesia
Molecular epidemiology of rabies in Indonesia
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DOI：
10.1016/j.virusres.2008.03.001
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发表时间：
2008-07-01
期刊：
影响因子：
5
通讯作者：
Minamoto, Nobuyuki
中科院分区：
文献类型：
--
作者：
Susetya, Heru;Sugiyama, Makoto;Minamoto, Nobuyuki
为了弄清在印度尼西亚流行的狂犬病病毒的遗传关系和动态，我们测定和分析了从苏门答腊岛、爪哇、加里曼丹、苏拉威西和弗洛雷斯群岛采集的34株狂犬病病毒的核蛋白基因1307个核苷酸。系统进化分析结果表明，印度尼西亚的狂犬病分离株为一个聚类群，属于亚洲血统，与中国的狂犬病分离株亲缘关系较近，而与泰国、印度和斯里兰卡的狂犬病分离株无亲缘关系。印度尼西亚的狂犬病分离株分为3个系统群(ID1、ID2和ID3)，包括7个谱系。分离株的系统发育与地理分布有一定的相关性。ID1系统群的四个谱系(SC1、SC2、SO和ST)的分离物主要存在于苏门答腊岛。ST谱系的分离物在苏门答腊岛广泛分布，而SC1、SC2等谱系的分离物仅限于苏门答腊岛中部。ID2和ID3系统群分别包括一个谱系(IA)和两个谱系(KS和SF)。系统发育分析和历史背景分析结果表明，中国的狂犬病病毒可能是由于人类活动而转移到印度尼西亚并传播到各个岛屿的。(C)2008爱思唯尔B.V.保留所有权利。
In order to clarify the genetic relationships and dynamics of rabies viruses that are epidemic in Indonesia, we determined and analyzed 1307 nucleoticles of nucleoprotein genes of 34 rabies field isolates collected from Sumatra, Java, Kalimantan, Sulawesi and Flores islands. Results of phylogenetic analysis indicated that rabies isolates in Indonesia formed one cluster, were of Asian lineage, and were closely related to a rabies isolate in China rather than to rabies isolates in Thailand, India or Sri Lanka. Rabies isolates in Indonesia were divided into three phylogroups (ID1, ID2 and ID3) that included seven lineages. There was a correlation between phylogroup and geographical distribution of the isolates. Isolates in four lineages (SC1, SC2, SO and ST) of the ID1 phylogroup were mainly present in Sumatra. Isolates in the ST lineage were distributed widely in Sumatra, while isolates in the SC1, SC2 and SO lineages were limited to central Sumatra. ID2 and ID3 phylogroups included one lineage (IA) and two lineages (KS and SF), respectively. Results of phylogenetic analysis and historical background suggest that rabies viruses in China might have been transferred to Indonesia and spread to each island due to human activities. (c) 2008 Elsevier B.V. All rights reserved.