nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity, especially in the early stages.
nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity, especially in the early stages.
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DOI：
10.1111/acel.12754
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发表时间：
2018-06
期刊：
影响因子：
7.8
通讯作者：
Zhu DY
中科院分区：
文献类型：
--
作者：
Zhang Y;Zhu Z;Liang HY;Zhang L;Zhou QG;Ni HY;Luo CX;Zhu DY
在神经元中，神经元型一氧化氮合酶（nNOS）及其羧基末端PDZ配体（CAPON）之间蛋白质-蛋白质相互作用的增加有助于兴奋性毒性和异常树突棘发育，两者都参与阿尔茨海默病的发展。在阿尔茨海默病模型中，在体外用β淀粉样蛋白治疗后检测到nNOS-CAPON相互作用增加，与体内年龄匹配的背景小鼠相比，在APP/PS1小鼠（阿尔茨海默病的转基因小鼠模型）的海马中发现了类似的变化。在阻断nNOS-CAPON相互作用后，4个月大的APP/PS1小鼠的记忆得到了拯救，体内和体外树突损伤都得到了改善。此外，我们证明了Dexras 1的S-亚硝基化和ERK-CREB-BDNF通路的抑制可能是nNOS-CAPON相互作用的下游。
In neurons, increased protein–protein interactions between neuronal nitric oxide synthase (nNOS) and its carboxy‐terminal PDZ ligand (CAPON) contribute to excitotoxicity and abnormal dendritic spine development, both of which are involved in the development of Alzheimer's disease. In models of Alzheimer's disease, increased nNOS–CAPON interaction was detected after treatment with amyloid‐β in vitro, and a similar change was found in the hippocampus of APP/PS1 mice (a transgenic mouse model of Alzheimer's disease), compared with age‐matched background mice in vivo. After blocking the nNOS–CAPON interaction, memory was rescued in 4‐month‐old APP/PS1 mice, and dendritic impairments were ameliorated both in vivo and in vitro. Furthermore, we demonstrated that S‐nitrosylation of Dexras1 and inhibition of the ERK–CREB–BDNF pathway might be downstream of the nNOS–CAPON interaction.
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NOS1AP 对 NMDA 受体-nNOS 信号传导的作用机制。
影响因子：
5.3
作者：
Courtney MJ;Li LL;Lai YY
通讯作者：
Lai YY
DOI：
10.1083/jcb.200805132
发表时间：
2008-12-15
期刊：
The Journal of cell biology
影响因子：
--
作者：
Nikonenko I;Boda B;Steen S;Knott G;Welker E;Muller D
通讯作者：
Muller D
影响因子：
5.3
作者：
Soriano, Francesc X.;Martel, Marc-Andre;Papadia, Sofia;Vaslin, Anne;Baxter, Paul;Rickman, Colin;Forder, Joan;Tymianski, Michael;Duncan, Rory;Aarts, Michelle;Clarke, Peter;Wyllie, David J. A.;Hardingham, Giles E.
通讯作者：
Hardingham, Giles E.
影响因子：
4.8
作者：
De Felice, Fernanda G.;Velasco, Pauline T.;Klein, William L.
通讯作者：
Klein, William L.
影响因子：
4.7
作者：
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通讯作者：
He, Ling