Not "just" a coincidence: Frontal-striatal interactions in working memory and interval timing
Not "just" a coincidence: Frontal-striatal interactions in working memory and interval timing
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DOI：
10.1080/09658210344000404
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发表时间：
2005-04-01
期刊：
影响因子：
2.1
通讯作者：
Meck, WH
中科院分区：
文献类型：
--
作者：
Lustig, C;Matell, MS;Meck, WH
额叶皮层和基底神经节在工作记忆和短暂时间间隔的能力中发挥着核心作用。我们概述了最近的理论和实证工作，表明工作记忆和间隔计时不仅依赖于相同的解剖结构，而且依赖于特定刺激的相同神经表征。具体来说，皮质神经元可能以振荡方式放电以形成刺激的表征，并且纹状体（基底神经节结构）可以检测与重要事件同时发生的皮质放电模式。可以从参与表示的皮层神经元中提取有关刺激身份的信息，并且可以从它们的相对相位中提取有关持续时间的信息。从这些基于生物学的模型中得出的原理也非常适合一系列基于行为的模型，这些模型强调时间在许多工作记忆现象中的重要性。
The frontal cortex and basal ganglia play central roles in working memory and in the ability to time brief intervals. We outline recent theoretical and empirical work to suggest that working memory and interval timing rely not only on the same anatomic structures, but also on the same neural representation of a specific stimulus. Specifically, cortical neurons may fire in an oscillatory fashion to form representations of stimuli, and the striatum (a basal ganglia structure) may detect those patterns of cortical firing that occur co-incident to important events. Information about stimulus identity can be extracted from which cortical neurons are involved in the representation, and information about duration can be extracted from their relative phase. The principles derived from these biologically based models also fit well with a family of behaviourally based models that emphasise the importance of time in many working memory phenomena.