Molecular profiling of single cells and tissue specimens with quantum dots
Molecular profiling of single cells and tissue specimens with quantum dots
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DOI：
10.1016/s0167-7799(03)00209-9
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发表时间：
2003-09-01
影响因子：
17.3
通讯作者：
Nie, SM
中科院分区：
文献类型：
--
作者：
Gao, XH;Nie, SM
量子点是纳米尺度上的微小发光颗粒。它们正在成为一种新的生物标签，具有传统有机染料和荧光蛋白无法使用的特性和应用。根据科学和自然生物技术的报道，最近的进步导致了高度发光和稳定的量子点生物缀合物。这些生物偶联为研究基因，蛋白质和药物靶标的单个细胞，组织标本乃至活动物中的基因，蛋白质和药物靶标提供了新的可能性。
Quantum dots are tiny light-emitting particles on the nanometer scale. They are emerging as a new class of biological label with properties and applications that are not available with traditional organic dyes and fluorescent proteins. Recent advances, as reported in Science and Nature Biotechnology, have led to quantum dot bioconjugates that are highly luminescent and stable. These bioconjugates raise new possibilities for studying genes, proteins and drug targets in single cells, tissue specimens and even in living animals.