Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females.
Association of serum growth differentiation factor-15 with eGFR and hemoglobin in healthy older females.
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DOI：
10.1016/j.ijcha.2020.100651
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Nakajima T
中科院分区：
文献类型：
--
作者：
Yazawa H;Fukuda T;Kaneda H;Waku R;Sakuma M;Matsumoto A;Toyoda S;Abe S;Nakamura F;Inoue T;Nakajima T
细胞因子失衡引起的与肾功能障碍相关的贫血和肌肉减少症可能会导致老年人的生活质量下降。生长分化因子 15 (GDF-15) 与肾功能障碍相关，但其是否与贫血或肌肉减少症相关尚不清楚。在这项研究中，我们检查了日本健康社区老年女性中 GDF-15 与肾功能、血红蛋白和肌少症的关系。共有 66 名健康的社区老年女性（年龄：75.8 ± 6.2 岁）参加了这项研究。通过生物电阻抗分析测定骨骼肌质量指数。还评估了握力和行走速度。通过酶联免疫吸附测定测定血清 GDF-15 浓度，并测量血红蛋白 (Hb) 水平和估计肾小球滤过率 (eGFR)。血清 GDF-15 水平与年龄呈正相关，但与 eGFR 和步行速度呈负相关。在多元回归分析中，eGFR 和血红蛋白 (Hb) 是预测血清 GDF-15 水平的自变量，即使在调整年龄和体重指数后也是如此（eGFR：β = -0.423，p < 0.001；Hb：β = -0.363，p = 0.004）。血清 GDF-15 水平是预测 eGFR 和 Hb 的自变量。 Hb 和 eGFR 都是健康老年女性血清 GDF-15 浓度的预测因子。在这些社区居住的老年女性中，GDF-15 导致的肾功能障碍可能会伴有贫血，但不会出现肌肉减少症。
Anemia and sarcopenia associated with renal dysfunction caused by cytokine imbalance can contribute to decreased quality of life for older individuals. Growth differentiation factor-15 (GDF-15) is associated with renal dysfunction, although whether it is related to anemia or sarcopenia is unclear. In this study we examined the association of GDF-15 with renal function, hemoglobin and sarcopenia in healthy community-dwelling older females in Japan. A total of 66 healthy older community-dwelling females (age: 75.8 ± 6.2 years) were enrolled for this study. Skeletal muscle mass index was determined by bioelectrical impedance analysis. Hand-grip strength and walking speed were also assessed. Serum GDF-15 concentration was determined by enzyme-linked immunosorbent assay and both hemoglobin (Hb) level and estimated glomerular filtration rate (eGFR) were measured. Serum GDF-15 levels positively correlated with age but negatively correlated with eGFR and walking speed. In multiple regression analysis, eGFR and hemoglobin (Hb) were independent variables to predict serum GDF-15 levels, even after adjusting for age and body mass index (eGFR: β = −0.423, p < 0.001; Hb: β = −0.363, p = 0.004). Serum GDF-15 level was an independent variable to predict eGFR and Hb. Both Hb and eGFR are predictors for serum GDF-15 concentration in healthy older females. In these community-dwelling older females, renal dysfunction via GDF-15 may be accompanied by anemia, but not sarcopenia.
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影响因子：
2.8
作者：
Kim, Jin Sug;Kim, Sunyoung;Jeong, Kyung Hwan
通讯作者：
Jeong, Kyung Hwan
影响因子：
20.1
作者：
Kempf, T;Eden, M;Wollert, KC
通讯作者：
Wollert, KC
影响因子：
13.6
作者：
Xue, Jay L.;Daniels, Frank;Collins, Allan J.
通讯作者：
Collins, Allan J.
DOI：
10.1111/j.1532-5415.2004.52502.x
发表时间：
2004-11-01
影响因子：
6.3
作者：
Chaves, PHM;Xue, QL;Fried, LP
通讯作者：
Fried, LP
影响因子：
16.2
作者：
Lajer M;Jorsal A;Tarnow L;Parving HH;Rossing P
通讯作者：
Rossing P