Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
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DOI：
10.1097/00001756-200410050-00019
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发表时间：
2004-10-05
期刊：
影响因子：
1.7
通讯作者：
Pei, JJ
中科院分区：
文献类型：
--
作者：
Li, X;An, WL;Pei, JJ
真核生物翻译因子4E （eIF4E）在蛋白质翻译调控中起关键作用。人们认为，为了维持神经元功能，tau蛋白不断产生，以补偿那些在阿尔茨海默病中被过度磷酸化和其促进和维持微管组装能力受损的蛋白。如果eIF4E参与tau mRNA的翻译，那么eIF4E的磷酸化水平应该是改变的。在目前的研究中，我们发现磷酸化的eIF4E在阿尔茨海默病中显著增加，特别是在那些晚期神经原纤维改变的病例中。eIF4E磷酸化水平与总磷酸化和阿尔茨海默病过度磷酸化tau蛋白显著相关。这些数据表明，eIF4E磷酸化的增加参与了阿尔茨海默病神经原纤维改变的形成。
Eukaryotic translation factor 4E (eIF4E) plays a key role in regulating protein translation. It was thought that in order to maintain neuronal functions, tau protein is continuously generated to compensate those being hyperphosphorylated and compromised in its ability to promote and maintain microtubule assembly in Alzheimer's disease. If eIF4E is involved in tau mRNA translation, level of eIF4E phosphorylation should be changed. In the current study, we found a dramatic increase of phosphorylated eIF4E in Alzheimer's disease, especially in those cases with late stages of neurofibrillary changes. Level of eIF4E phosphorylation is significantly correlated with total- and Alzheimer hyperphosphorylated taus. These data suggest that the increase of eIF4E phosphorylation is involved in formation of Alzheimer neurofibrillary changes.