Atypicality of the N170 Event-Related Potential in Autism Spectrum Disorder: A Meta-analysis
Atypicality of the N170 Event-Related Potential in Autism Spectrum Disorder: A Meta-analysis
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DOI：
10.1016/j.bpsc.2017.11.003
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发表时间：
2018-08-01
影响因子：
5.9
通讯作者：
Lerner, Matthew D.
中科院分区：
文献类型：
--
作者：
Kang, Erin;Keifer, Cara M.;Lerner, Matthew D.
背景：自闭症谱系障碍（ASD）与受损的面部处理有关。N170事件相关电位（ERP）已被认为是一个有前途的神经标志物，这种损害。然而，没有定量的审查，迄今已整合的文献，以评估是否N170响应与ASD的个人面临的不同，从典型的发展（TD）individuals.METHODS：这项荟萃分析研究的语料库的文献调查的差异，在N170响应与ASD和没有ASD的个人面临的。回顾了23项研究（N-ASD = 374，N-TD = 359）的数据。荟萃分析用于检查ASD和非ASD个体之间N170潜伏期和振幅差异的效应量。还进行了分析，检查半球的差异，潜在的主持人，和出版bias.RESULTS：平均而言，N170潜伏到面孔的ASD个体延迟，但幅度没有不同的ASD和TD个人的个人。主持人分析显示，N170振幅较小的幅度在ASD参与者相对于TD参与者在成人样本和那些具有较高的认知能力。然而，效果不同的功能半球的记录。没有证据表明出版偏见被发现。结论：不典型的N170 -特别是潜伏期，以面对似乎是一个特定的生物标志物的社会交往功能障碍，在ASD，并可能涉及到不同的发展经验和使用的补偿认知机制。未来的研究应该检查导致N170异质性的表型差异，以及ASD与非ASD临床人群中N170差异的特异性，以及N170治疗的延展性。
BACKGROUND: Autism spectrum disorder (ASD) is associated with impaired face processing. The N170 event-related potential (ERP) has been considered a promising neural marker of this impairment. However, no quantitative review to date has integrated the literature to assess whether the N170 response to faces in individuals with ASD differs from that of typically developing (TD) individuals.METHODS: This meta-analysis examined the corpus of literature investigating difference in N170 response to faces in individuals with ASD and without ASD. Data from 23 studies (N-ASD = 374, N-TD = 359) were reviewed. Meta-analysis was used to examine the effect size of the difference in N170 latency and amplitude among individuals with ASD and without ASD. Analyses were also conducted examining hemispheric differences, potential moderators, and publication bias.RESULTS: On average, N170 latencies to faces were delayed in individuals with ASD, but amplitudes did not differ for individuals with ASD and TD individuals. Moderator analyses revealed that N170 amplitudes were smaller in magnitude in the ASD participants relative to the TD participants in adult samples and in those with higher cognitive ability. However, effects differed as a function of hemisphere of recording. No evidence of publication bias was found.CONCLUSIONS: Atypicality of N170 - particularly latency-to faces appears to be a specific biomarker of social-communicative dysfunction in ASD and may relate to differential developmental experiences and use of compensatory cognitive mechanisms. Future research should examine phenotypic differences that contribute to N170 heterogeneity, as well as specificity of N170 differences in ASD versus non-ASD clinical populations, and N170 malleability with treatment.