Modulation of force induced by pH in the guinea-pig uterus examined at two stages of the oestrous cycle
Modulation of force induced by pH in the guinea-pig uterus examined at two stages of the oestrous cycle
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DOI：
10.1530/jrf.0.1170153
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发表时间：
1999-09-01
期刊：
影响因子：
--
通讯作者：
Wray, S
中科院分区：
文献类型：
--
作者：
Naderali, EK;Wray, S
pH值的变化对子宫收缩力有显著影响。子宫pH值的变化发生在怀孕和分娩期间，此时发生明显的内分泌变化。由于激素状态也会影响收缩力，因此本研究调查了pH诱导的子宫力调节是否受激素变化的影响。在豚鼠发情周期的第7天（高孕酮）和第15天（低孕酮），研究了改变细胞内和细胞外pH值对子宫收缩的影响。与第7天相比，第15天的静息pH值显着更酸性，并且第15天产生了更多的力量。改变外部pH值产生类似的变化，细胞内pH值和力的两天。外部酸化与武力的大幅增加有关。相反，细胞内酸化，在恒定的外部pH值，减少力。总之，发情周期的阶段有很大的影响，在子宫肌层的静息pH值，但只有小的影响，我诱导的力的调制，pH值和力之间的联系是复杂的。
Changes in pH have a marked influence on uterine contractility. Changes in uterine pH occur during pregnancy and labour, when marked endocrine changes are occurring. As hormonal status can also influence contractility, this study investigated whether pH-induced modulation of uterine force is influenced by hormonal changes. The effects of altering intracellular and extracellular pH on uterine contractions were studied in guinea-pigs on day 7 (high progesterone) and day 15 (low progesterone) of the oestrous cycle. Resting values of pH were significantly more acidic on day 15 compared with day 7, and more force was produced on day 15. Changing external pH produced similar changes in intracellular pH and force on both days. External acidification was associated with a large increase in force. In contrast, intracellular acidification, at constant external pH, reduced force. In conclusion, the stage of the oestrous cycle has a large effect on resting pH in the myometrium but only small effects on the pi-I-induced modulation of force, and the link between pH and force is complex.