Evidence for field effect cancerization in colorectal cancer
Evidence for field effect cancerization in colorectal cancer
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DOI：
10.1016/j.ygeno.2013.11.003
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发表时间：
2014-02-01
期刊：
影响因子：
4.4
通讯作者：
Mojica, W.
中科院分区：
文献类型：
--
作者：
Hawthorn, L.;Lan, L.;Mojica, W.
我们比较了一系列肿瘤和周围组织的转录表达和染色体变化，以确定结直肠癌中是否有实地癌变的证据。从肿瘤和肿瘤附近1 - 10 cm的区域分离上皮细胞。肿瘤异常反映了先前报道的结肠癌，虽然周围区域的细胞中染色体异常的数量和大小大大减少，但许多染色体异常是可辨别的。有趣的是，这些异常在同一患者样本中的视野中并不一致，表明肿瘤周围存在染色体不稳定性。已经提出了一种突变表型来解释这种不稳定性，其表明肿瘤内细胞的基因型不相同，但在任何数量的基因中至少共享一个突变，或者选择影响提供增殖优势的特定途径的基因。(C)2013作者爱思唯尔公司出版这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/3.0/）。
We compared transcript expression, and chromosomal changes on a series of tumors and surrounding tissues to determine if there is evidence of field cancerization in colorectal cancer. Epithelial cells were isolated from tumors and areas adjacent to the tumors ranging from 1 to 10 cm. Tumor abnormalities mirrored those previously reported for colon cancer and while the number and size of the chromosomal abnormalities were greatly reduced in cells from surrounding regions, many chromosome abnormalities were discernable. Interestingly, these abnormalities were not consistent across the field in the same patient samples suggesting a field of chromosomal instability surrounding the tumor. A mutator phenotype has been proposed to account for this instability which states that the genotypes of cells within a tumor would not be identical, but would share at least a single mutation in any number of genes, or a selection of genes affecting a specific pathway which provide a proliferative advantage. (C) 2013 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).